Science & Publications

A. Sally Davis, D.V.M., Ph.D.

• Diplomate, ACVP and ACVM
• Program Graduate 2014

• Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2
• Schirtzinger EE, Kim Y, Davis AS
• J Virol Methods. 2022 Jan;299:114317. doi: 10.1016/j.jviromet.2021.114317. Epub 2021 Oct 9.
• PMID: 34634321

• Vaccination with Rift Valley fever virus live attenuated vaccine strain Smithburn caused meningoencephalitis in alpacas
• Anthony T, van Schalkwyk A, Romito M, Odendaal L, Clift SJ, Davis AS.
• J Vet Diagn Invest. 2021 Jul;33(4):777-781. doi: 10.1177/10406387211015294. Epub 2021 May 27.
• PMID: 34041966

• Insights into the Pathogenesis of Viral Haemorrhagic Fever Based on Virus Tropism and Tissue Lesions of Natural Rift Valley Fever
• Odendaal L, Davis AS, Venter EH.
• Viruses. 2021 Apr 20;13(4). doi: 10.3390/v13040709. Review.
• PMID: 33923863

• The Use of Quantitative Digital Pathology to Measure Proteoglycan and Glycosaminoglycan Expression and Accumulation in Healthy and Diseased Tissues
• Davis AS, Chang MY, Brune JE, Hallstrand TS, Johnson B, Lindhartsen S, Hewitt SM, Frevert CW.
• J Histochem Cytochem. 2021 Feb;69(2):137-155. doi: 10.1369/0022155420959146. Epub 2020 Sep 16. Review.
• PMID: 32936035

• Retrospective phylogenetic analyses of formalin-fixed paraffin-embedded samples from the 2011 Rift Valley fever outbreak in South Africa, through sequencing of targeted regions
• van Schalkwyk A, Gwala S, Schuck KN, Quan M, Davis AS, Romito M, Odendaal L.
• J Virol Methods. 2021 Jan;287:114003. doi: 10.1016/j.jviromet.2020.114003. Epub 2020 Oct 23.
• PMID: 33164863

• Ovine Fetal and Placental Lesions and Cellular Tropism in Natural Rift Valley Fever Virus Infections
• Odendaal L, Clift SJ, Fosgate GT, Davis AS.
• Vet Pathol. 2020 Nov;57(6):791-806. doi: 10.1177/0300985820954549. Epub 2020 Sep 4.
• PMID: 32885745

• MUC1 mediates Pneumocystis murina binding to airway epithelial cells
• Liu Y, Davis AS, Ma L, Bishop L, Cissé OH, Kutty G, Kovacs JA.
• Cell Microbiol. 2020 Jun;22(6):e13182. doi: 10.1111/cmi.13182. Epub 2020 Feb 19.
• PMID: 32017380

• Lesions and Cellular Tropism of Natural Rift Valley Fever Virus Infection in Young Lambs
• Odendaal L, Davis AS, Fosgate GT, Clift SJ.
• Vet Pathol. 2020 Jan;57(1):66-81. doi: 10.1177/0300985819882633. Epub 2019 Dec 17.
• PMID: 31842723

• Rift Valley Fever Virus: Propagation, Quantification, and Storage
• Smith MR, Schirtzinger EE, Wilson WC, Davis AS.
• Curr Protoc Microbiol. 2019 Dec;55(1):e92. doi: 10.1002/cpmc.92.
• PMID: 31763765

• Immunogenicity and efficacy of Schmallenberg virus envelope glycoprotein subunit vaccines
• Endalew AD, Faburay B, Trujillo JD, Gaudreault NN, Davis AS, Shivanna V, Sunwoo SY, Ma W, Drolet BS, McVey DS, Morozov I, Wilson WC, Richt JA.
• J Vet Sci. 2019 Nov;20(6):e58. doi: 10.4142/jvs.2019.20.e58.
• PMID: 31775185

• Comparative evaluation of pathogenicity of three isolates of vesicular stomatitis virus (Indiana serotype) in pigs
• Morozov I, Davis AS, Ellsworth S, Trujillo JD, McDowell C, Shivanna V, Dasen EJ, Nichols R, Martin BK, Monath TP, Richt JA.
• J Gen Virol. 2019 Nov;100(11):1478-1490. doi: 10.1099/jgv.0.001329. PubMed PMID: 31553299.
• PMID: 31553299

• Characterization of Pneumocystis murina Bgl2, an Endo-β-1,3-Glucanase and Glucanosyltransferase
• Kutty G, Davis AS, Schuck K, Masterson M, Wang H, Liu Y, Kovacs JA.
• J Infect Dis. 2019 Jul 19;220(4):657-665. doi: 10.1093/infdis/jiz172.
• PMID: 31100118

• Rift Valley Fever Viral RNA Detection by In Situ Hybridization in Formalin-Fixed, Paraffin-Embedded Tissues
• Ragan IK, Schuck KN, Upreti D, Odendaal L, Richt JA, Trujillo JD, Wilson WC, Davis AS.
• Vector Borne Zoonotic Dis. 2019 Jul;19(7):553-556. doi: 10.1089/vbz.2018.2383. Epub 2019 Feb 13.
• PMID: 30720389

• Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares ( Aplysia californica)
• Mason SE, Papich MG, Schmale MC, Harms CA, Davis SA.
• J Am Assoc Lab Anim Sci. 2019 Mar 1;58(2):231-234. doi: 10.30802/AALAS-JAALAS-18-000072. Epub 2019 Feb 28.
• PMID: 30819273

• Lesions and Cellular Tropism of Natural Rift Valley Fever Virus Infection in Adult Sheep
• Odendaal L, Clift SJ, Fosgate GT, Davis AS.
• Vet Pathol. 2019 Jan;56(1):61-77. doi: 10.1177/0300985818806049. Epub 2018 Oct 21.
• PMID: 30343650

• Virological and Serological Responses of Sheep and Cattle to Experimental Schmallenberg Virus Infection
• select Endalew AD, Morozov I, Davis AS, Gaudreault NN, Wernike K, Bawa B, Ruder MG, Drolet BS, McVey DS, Shivanna V, Ma W, Faburay B, Wilson WC, Richt JA.
• Vector Borne Zoonotic Dis. 2018 Dec;18(12):697-703. doi: 10.1089/vbz.2018.2297. Epub 2018 Aug 15.
• PMID: 30109977

• Preliminary evaluation of diagnostic accuracy and precision of a competitive ELISA for detection of antibodies to Rift Valley fever virus in cattle and sheep sera.
• Upreti D, Cernicchiaro N, Richt JA, Wilson WC, Clavijo A, Davis AS.
• J Virol Methods. 2018 Dec;262:6-11. doi: 10.1016/j.jviromet.2018.09.002. Epub 2018 Sep 8.
• PMID: 30205125

• A Universal Influenza Virus Vaccine Candidate Tested in a Pig Vaccination-Infection Model in the Presence of Maternal Antibodies.
• Sunwoo SY, Schotsaert M, Morozov I, Davis AS, Li Y, Lee J, McDowell C, Meade P, Nachbagauer R, García-Sastre A, Ma W, Krammer F, Richt JA.
• Vaccines (Basel). 2018 Sep 14;6(3). doi: 10.3390/vaccines6030064.
• PMID: 30223475

• Characterization of p57, a Stage-Specific Antigen of Pneumocystis murina.
• Bishop LR, Davis AS, Bradshaw K, Gamez M, Cisse OH, Wang H, Ma L, Kovacs JA.
• J Infect Dis. 2018 Jun 20;218(2):282-290. doi: 10.1093/infdis/jiy099.
• PMID: 29471356

• Evaluation of Fluorescence Microsphere Immunoassay for Detection of Antibodies to Rift Valley Fever Virus Nucleocapsid Protein and Glycoproteins.
• Ragan IK, Davis AS, McVey DS, Richt JA, Rowland RR, Wilson WC.
• J Clin Microbiol. 2018 Jun;56(6). doi: 10.1128/JCM.01626-17. Print 2018 Jun.
• PMID: 29563201

• Newcastle disease virus-based H5 influenza vaccine protects chickens from lethal challenge with a highly pathogenic H5N2 avian influenza virus.
• Ma J, Lee J, Liu H, Mena I, Davis AS, Sunwoo SY, Lang Y, Duff M, Morozov I, Li Y, Yang J, García-Sastre A, Richt JA, Ma W.
• NPJ Vaccines. 2017;2:33. doi: 10.1038/s41541-017-0034-4. eCollection 2017.
• PMID: 29263888

• β-Glucans Are Masked but Contribute to Pulmonary Inflammation During Pneumocystis Pneumonia.
• Kutty G, Davis AS, Ferreyra GA, Qiu J, Huang da W, Sassi M, Bishop L, Handley G, Sherman B, Lempicki R, Kovacs JA.
• J Infect Dis. 2016 Sep 1;214(5):782-91. doi: 10.1093/infdis/jiw249. Epub 2016 Jun 19.
• PMID: 27324243

• A Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Confers Full Protection against Rift Valley Fever Challenge in Sheep.
• Faburay B, Wilson WC, Gaudreault NN, Davis AS, Shivanna V, Bawa B, Sunwoo SY, Ma W, Drolet BS, Morozov I, McVey DS, Richt JA.
• Sci Rep. 2016 Jun 14;6:27719. doi: 10.1038/srep27719.
• PMID: 27296136

• 1918 Influenza receptor binding domain variants bind and replicate in primary human airway cells regardless of receptor specificity.
• Davis AS, Chertow DS, Kindrachuk J, Qi L, Schwartzman LM, Suzich J, Alsaaty S, Logun C, Shelhamer JH, Taubenberger JK.
• Virology. 2016 Jun;493:238-46. doi: 10.1016/j.virol.2016.03.025. Epub 2016 Apr 11.
• PMID: 27062579

• Experimental Infection of Calves by Two Genetically-Distinct Strains of Rift Valley Fever Virus.
• Wilson WC, Davis AS, Gaudreault NN, Faburay B, Trujillo JD, Shivanna V, Sunwoo SY, Balogh A, Endalew A, Ma W, Drolet BS, Ruder MG, Morozov I, McVey DS, Richt JA.
• Viruses. 2016 May 23;8(5). doi: 10.3390/v8050145.
• PMID: 27223298

• Development of a sheep challenge model for Rift Valley fever.
• Faburay B, Gaudreault NN, Liu Q, Davis AS, Shivanna V, Sunwoo SY, Lang Y, Morozov I, Ruder M, Drolet B, Scott McVey D, Ma W, Wilson W, Richt JA.
• Virology. 2016 Feb;489:128-40. doi: 10.1016/j.virol.2015.12.003. Epub 2015 Dec 31.
• PMID: 26748334

• Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin
• Qi L, Pujanauski LM, Davis AS, Schwartzman LM, Chertow DS, Baxter D, Scherler K, Hartshorn KL, Slemons RD, Walters KA, Kash JC, Taubenberger JK.
• mBio. 2014 Nov 18;5(6):e02116. doi: 10.1128/mBio.02116-14.
• PMID: 25406382

• The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.
• Davis AS, Taubenberger JK, Bray M.
• Antiviral Res. 2015 May;117:75-98. doi: 10.1016/j.antiviral.2015.02.011. Epub 2015 Mar 5. Review.
• PMID: 25746173

• Validation of normal human bronchial epithelial cells as a model for influenza A infections in human distal trachea.
• Davis AS, Chertow DS, Moyer JE, Suzich J, Sandouk A, Dorward DW, Logun C, Shelhamer JH, Taubenberger JK.
• J Histochem Cytochem. 2015 May;63(5):312-28. doi: 10.1369/0022155415570968. Epub 2015 Jan 20.
• PMID: 25604814

• Pneumocystis Encodes a Functional Endo-β-1,3-glucanase That is Expressed Exclusively in Cysts.
• Kutty G, Davis AS, Ma L, Taubenberger JK, Kovacs JA.
• J Infect Dis. 2014 Sep 17. pii: jiu517. [Epub ahead of print]
• PMID: 25231017

• Characterizing and Diminishing Autofluorescence in Formalin-fixed Paraffin-embedded Human Respiratory Tissue.
• Davis AS, Richter A, Becker S, Moyer JE, Sandouk A, Skinner J, Taubenberger JK.
• J Histochem Cytochem. 2014 Apr 30. [Epub ahead of print]
• PMID: 24722432

• Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.
• Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK.
• Free Radic Biol Med. 2013 Oct 17;67C:235-247. doi: 10.1016/ j.freeradbiomed.2013.10.014. [Epub ahead]
• PMID: 24140866

• Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells.
• Martinez-Anton A, Sokolowska M, Kern S, Davis AS, Alsaaty S, Taubenberger JK, Sun J, Cai R, Danner RL, Eberlein M, Logun C, ShelhamerJH.
• Am J Respir Cell Mol Biol. 2013 Apr 13.
• PMID: 23590309

• Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.
• Qi L, Davis AS, Jagger BW, Schwartzman LM, Dunham EJ, Kash JC, Taubenberger JK.
• J Virol. 2012 Sep;86(17):9211-20. doi: 10.1128/JVI.00887-12. Epub 2012 Jun 20.
• PMID: 22718825

• In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient.
• Memoli MJ, Bristol T, Proudfoot KE, Davis AS, Dunham EJ, Taubenberger JK.
• Virology. 2012 Jun 20;428(1):21-9. doi: 10.1016/j.virol.2012.02.018.
• PMID: 22575875

• Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses.
• Kash JC, Walters KA, Davis AS, Sandouk A, Schwartzman LM, Jagger BW, Chertow DS, Li Q, Kuestner RE, Ozinsky A, Taubenberger JK.
• MBio. 2011 Sep 20;2(5). pii: e00172-11. doi: 10.1128/mBio.00172-11. Print 2011.
• PMID: 21933918

• Global rinderpest eradication: lessons learned and why humans should celebrate too.
• Morens DM, Holmes EC, Davis AS, Taubenberger JK.
• J Infect Dis. 2011 Aug 15;204(4):502-5. doi: 10.1093/infdis/jir327.
• PMID: 21653230

• Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets.
• Memoli MJ, Davis AS, Proudfoot K, Chertow DS, Hrabal RJ, Bristol T, Taubenberger JK.
• J Infect Dis. 2011 Feb 1;203(3):348-57. doi: 10.1093/infdis/jiq067. Epub 2010 Dec 20.
• PMID: 21208927

• Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.
• Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE.
• Cancer Res. 2010 Jul 15;70(14):5706-16. Epub 2010 Jun 22.
• PMID: 20570886

• Gross and histologic evaluation of 5 suture materials in the skin and subcutaneous tissue of the California sea hare (Aplysia californica).
• Anderson ET, Davis AS, Law JM, Lewbart GA, Christian LS, Harms CA.
• J Am Assoc Lab Anim Sci. 2010 Jan;49(1):64-8.
• PMID: 20122319

• PMID:

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Amy Flis, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2023

• Understanding the Role of Dopamine in Cancer: Past, Present, and Future.
• Grant CE, Flis AL, Ryan BM
• Carcinogenesis, 2022. 43 (6): 517–527, doi: 10.1093/carcin/bgac045.
• PMID: 35616105

• DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC
• Grant CE, Flis AL, Toulabi L, Zingone A, Rossi E, Aploks K, Sheppard H, Ryan BM.
• Mol Oncol. 2024 Apr 4. doi: 10.1002/1878-0261.13608.
• PMID: 38572507

• PMID:

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Amy McCalla, D.V.M., Ph.D.

• PROGRAM GRADUATE 2019

• A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.
• Ferraz Nogueira Filho MA, Peer CJ, Nguyen J, McCalla A, Helman L, Figg WD.
• J Pharm Biomed Anal. 2017 Jan 5;132:223-226. doi: 10.1016/j.jpba.2016.10.003.
• PMID: 2776892

• Polyomavirus-associated nephritis in 2 horses.
• Jennings SH, Wise AG, Nickeleit V, Maes RK, Cianciolo RE, Del Piero F, Law JM, Kim Y, McCalla AC, Breuhaus BA, Roberts MC, Linder KE.
• Vet Pathol. 2013 Sep;50(5):769-74. doi: 10.1177/0300985813476063. Epub 2013 Feb 4.
• PMID: 23381926

• Vesiculobullous skin reaction temporally related to firocoxib treatment in a white rhinoceros (Ceratotherium simum).
• Stringer EM, De Voe RS, Linder K, Troan B, McCalla-Martin A, Loomis MR.
• J Zoo Wildl Med. 2012 Mar;43(1):186-9.
• PMID: 22448531

• Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N.
• McCalla-Martin AC, Chen X, Linder KE, Estrada JL, Piedrahita JA.
• Transgenic Res. 2010 Oct;19(5):869-87. Epub 2010 Jan 23.
• PMID: 20099029

• Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.
• Freeman-Anderson NE, Zheng Y, McCalla-Martin AC, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham JM, Skapek SX.
• Development. 2009 Jun;136(12):2081-9.
• PMID: 19465598

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David Caudell, D.V.M., Ph.D.

• Program Graduate 2008

• Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.
• Novak RL, Harper DP, Caudell D, Slape C, Beachy SH, Aplan PD.
• Exp Hematol. 2012 Dec;40(12):1016-27. doi: 10.1016/j.exphem.2012.08.001. Epub 2012 Aug 8.
• PMID: 22885519

• Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.
• Caudell D, Harper DP, Novak RL, Pierce RM, Slape C, Wolff L, Aplan PD.
• Blood. 2010 Feb 11;115(6):1194-203. Epub 2009 Dec 9.
• PMID: 20007546

• The role of CALM-AF10 gene fusion in acute leukemia.
• Caudell D, Aplan PD.
• Leukemia. 2008 Apr;22(4):678-85. Epub 2007 Dec 20. Review.
• PMID: 18094714

• Quantification of HTLV-I proviral load in experimentally infected rabbits.
• Zhao TM, Hague B, Caudell DL, Simpson RM, Kindt TJ.
• Retrovirology. 2005 May 23;2:34.
• PMID: 15910683

• Ocular penetration of oral doxycycline in the horse.
• Gilmour MA, Clarke CR, Macallister CG, Dedeo JM, Caudell DL, Morton RJ, Pugh M.
• Vet Ophthalmol. 2005 Sep-Oct;8(5):331-5.
• PMID: 16178844

• Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy.
• Caudell D, Confer AW, Fulton RW, Berry A, Saliki JT, Fent GM, Ritchey JW.
• J Vet Diagn Invest. 2005 Jan;17(1):58-61. Erratum in: J Vet Diagn Invest. 2005 Sep;17(5):502.
• PMID: 15690952

• Paresis secondary to an extradural hematoma in a Sumatran tiger (Panthera tigris sumatrae).
• Ketz-Riley CJ, Galloway DS, Hoover JP, Rochat MC, Bahr RJ, Ritchey JW, Caudell DL.
• J Zoo Wildl Med. 2004 Jun;35(2):208-15.
• PMID: 15305517

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Heather Shive, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2010

• brca2 and tp53 Collaborate in Tumorigenesis in Zebrafish.
• Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD.
• PLoS One. 2014 Jan 29;9(1):e87177. doi: 10.1371/journal.pone.0087177. eCollection 2014.
• PMID: 24489863

• Zebrafish models for human cancer.
• Shive HR
• Vet Pathol. 2013 May;50(3):468-82. doi: 10.1177/0300985812467471. Epub 2012 Nov 30.
• PMID: 23203679

• Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.
• Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J.
• J Proteome Res. 2012 Mar 2;11(3):1561-70. doi: 10.1021/pr200612y. Epub 2012 Feb 6.
• PMID: 22214408

• brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
• Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD.
• Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5. Epub 2010 Oct 25.
• PMID: 20974951

• Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.
• Russell-Lodrigue KE, Andoh M, Poels MW, Shive HR, Weeks BR, Zhang GQ, Tersteeg C, Masegi T, Hotta A, Yamaguchi T, Fukushi H, Hirai K, McMurray DN, Samuel JE.
• Infect Immun. 2009 Dec;77(12):5640-50. Epub 2009 Sep 28.
• PMID: 19786560

• T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.
• Andoh M, Zhang G, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE.
• Infect Immun. 2007 Jul;75(7):3245-55. Epub 2007 Apr 16.
• PMID: 17438029

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Heather Tillman, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2015

• Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.
• Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K.
• Cell Rep. 2015 Dec 15;13(10):2147-58. doi: 10.1016/j.celrep.2015.10.077. Epub 2015 Nov 25.
• PMID: 26628377

• EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1.
• Chang YS, Chen WY, Yin JJ, Tillman H, Huang J, Liu YN.
• Cancer Res. 2015 Jun 12. pii: canres.3380.2014. [Epub ahead of print]
• PMID: 26071255

• Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.
• Liu YN, Yin J, Barrett B, Sheppard-Tillman H, Li D, Casey OM, Fang L, Hynes PG, Ameri AH, Kelly K.
• Mol Cell Biol. 2015 Jun 1;35(11):1940-51. doi: 10.1128/MCB.00008-15. Epub 2015 Mar 23.
• PMID: 25802280

• AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis.
• Yin J*, Liu YN*, Tillman H*, Barrett B, Hewitt S, Ylaya K, Fang L, Lake R, Corey E, Morrissey C, Vessella R, Kelly K
• Cancer Res. 2014 Aug 15;74(16):4306-17. doi: 10.1158/0008-5472.CAN-13-3233. Epub 2014 Jun 26.
• PMID: 24970477

• MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
• Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
• Oncogene. 2013 Jan 17;32(3):296-306. doi: 10.1038/onc.2012.58. Epub 2012 Feb 27.
• PMID: 22370643

• Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.
• Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
• Mol Cell Biol. 2012 Mar;32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27.
• PMID: 22203039

• TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.
• Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.
• PLoS One. 2012;7(7):e41668. doi: 10.1371/journal.pone.0041668. Epub 2012 Jul 30.
• PMID: 22860005

• Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
• Wei BR, Edwards JB, Hoover SB, Tillman HS, Reed LT, Sills RC, Simpson RM.
• Toxicol Pathol. 2008;36(7):972-80. Epub 2008 Oct 31
• PMID: 18978308

• Protein expression profiling of normal and neoplastic canine prostate and bladder tissue.
• LeRoy B, Painter A, Sheppard H, Popiolek L, Samuel-Foo M, Andacht TM.
• Vet Comp Oncol. 2007 Jun;5(2):119-30.
• PMID: 19754795

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Helen Michael, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2018

• Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice.
• Michael HT, Graff-Cherry C, Chin S, Rauck C, Habtemichael AD, Bunda P, Smith T, Campos MM, Bharti K, Arnheiter H, Merlino G, Day CP.
• Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):6067-6073. doi: 10.1167/iovs.18-25186.
• PMID: 30590377

• Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia.
• Cramer SD, Hixon JA, Andrews C, Porter RJ, Rodrigues GOL, Wu X, Back T, Czarra K, Michael H, Cam M, Chen J, Esposito D, Senkevitch E, Negi V, Aplan PD, Li W, Durum SK.
• Leukemia. 2018 Aug;32(8):1795-1882. doi: 10.1038/s41375-017-0001-0. Epub 2018 Feb 15.
• PMID: 29535426

• Naturally Occurring Canine Melanoma as a Predictive Comparative Oncology Model for Human Mucosal and Other Triple Wild-Type Melanomas.
• Hernandez B, Adissu HA, Wei BR, Michael HT, Merlino G, Simpson RM.
• Int J Mol Sci. 2018 Jan 30;19(2). pii: E394. doi: 10.3390/ijms19020394.
• PMID: 29385676

• A Topical Solution to the Sunless Tanning Problem.
• Michael HT, Merlino G.
• Trends Mol Med. 2017 Sep;23(9):771-773. doi: 10.1016/j.molmed.2017.07.010. Epub 2017 Aug 5.
• PMID: 28789829

• Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.
• Day CP, Marchalik R, Merlino G, Michael H.
• Lab Invest. 2017 Jan 16. doi: 10.1038/labinvest.2016.155. [Epub ahead of print]
• PMID: 28092363

• Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.
• Wei BR, Michael HT, Halsey CH, Peer CJ, Adhikari A, Dwyer JE, Hoover SB, El Meskini R, Kozlov S, Weaver Ohler Z, Figg WD, Merlino G, Simpson RM.
• Pigment Cell Melanoma Res. 2016 Jul 27. doi: 10.1111/pcmr.12512. [Epub ahead of print]
• PMID: 27463366

• Functional analysis of prognostic gene expression network genes in metastatic breast cancer models.
• Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW.
• PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014.
• PMID: 25368990

• Isolation and characterization of canine natural killer cells.
• Michael HT, Ito D, McCullar V, Zhang B, Miller JS, Modiano JF.
• Vet Immunol Immunopathol. 2013 Sep 15;155(3):211-7. doi: 10.1016/j.vetimm.2013.06.013. Epub 2013 Jun 28
• PMID: 23876304

• Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
• Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.
• Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21
• PMID: 24128326

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Ian Moore, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2014

• Mucosal prime-boost immunization with live murine pneumonia virus-vectored SARS-CoV-2 vaccine is protective in macaques.
• Buchholz U, Kaiser J, Nelson C, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Ahlers L, Herbert R, Moore I, Wilder-Kofie T, Moore R, Walker A, Lijuan Y, Munir S, Teng IT, Kwong P, Dowdell K, Nguyen H, Kim J, Cohen J, Johnson RF, Garza N, Via L, Barber D, Nouen CL.
• https://pubmed.ncbi.nlm.nih.gov/37790295/
• PMID:

• Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in monkeys.
• Le Nouën C, Nelson CE, Liu X, Park HS, Matsuoka Y, Luongo C, Santos C, Yang L, Herbert R, Castens A, Moore IN, Wilder-Kofie T, Moore R, Walker A, Zhang P, Lusso P, Johnson RF, Garza NL, Via LE, Munir S, Barber DL, Buchholz UJ.
• J Comp Pathol. 2014 Nov;151(4):314-7. doi: 10.1016/j.jcpa.2014.08.004. Epub 2014 Sep 22.
• PMID: 36423629

• Breadth of SARS-CoV-2 neutralization and protection induced by a nanoparticle vaccine.
• Li D, Martinez DR, Schäfer A, Chen H, Barr M, Sutherland LL, Lee E, Parks R, Mielke D, Edwards W, Newman A, Bock KW, Minai M, Nagata BM, Gagne M, Douek DC, DeMarco CT, Denny TN, Oguin TH 3rd, Brown A, Rountree W, Wang Y, Mansouri K, Edwards RJ, Ferrari G, Sempowski GD, Eaton A, Tang J, Cain DW, Santra S, Pardi N, Weissman D, Tomai MA, Fox CB, Moore IN, Andersen H, Lewis MG, Golding H, Seder R, Khurana S, Baric RS, Montefiori DC, Saunders KO, Haynes BF.
• Nat Commun. (October 2022) 23;13(1):6309. doi: 10.1038/s41467-022-33985-4.
• PMID: 36274085

• mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing antibodies and protection against Omicron.
• Gagne, M., Moliva, J.I., Foulds, K.E., Andrew, S.F., Flynn, B.J., Werner, A.P., Wagner, D.A., Teng, I.-T., Lin, B.C., Moore, C., Jean-Baptiste, N., Carroll, R., Foster, S.L., Patel, M., Ellis, M., Edara, V.-V., Maldonado, N.V., Minai, M., McCormick, L., Honeycutt, C.C., Nagata, B.M., Bock, K.W., Dulan, C.N.M., Cordon, J., Flebbe, D.R., Todd, J.-P.M., McCarthy, E., Pessaint, L., Van Ry, A., Narvaez, B., Valentin, D., Cook, A., Dodson, A., Steingrebe, K., Nurmukhambetova, S.T., Godbole, S., Henry, A.R., Laboune, F., Roberts-Torres, J., Lorang, C.G., Amin, S., Trost, J., Naisan, M., Basappa, M., Willis, J., Wang, L., Shi, W., Doria-Rose, N.A., Zhang, Y., Yang, E.S., Leung, K., O’Dell, S., Schmidt, S.D., Olia, A.S., Liu, C., Harris, D.R., Chuang, G.-Y., Stewart-Jones, G., Renzi, I., Lai, Y.- T., Malinowski, A., Wu, K., Mascola, J.R., Carfi, A., Kwong, P.D., Edwards, D.K., Lewis, M.G., Andersen, H., Corbett, K.S., Nason, M.C., McDermott, A.B., Suthar, M.S., Moore, I.N., Roederer, M., Sullivan, N.J., Douek, D.C., Seder, R.A.
• Cell (March 2022). doi.org/10.1016/j.cell.2022.03.038.
• PMID: 35447072

• Bohrer AC, Castro E, Hu Z, Queiroz ATL, Tocheny CE, Assmann M, Sakai S, Nelson C, Baker PJ, Ma H, Wang L, Zilu W, du Bruyn E, Riou C, Kauffman KD; Tuberculosis Imaging Program; Moore IN, Del Nonno F, Petrone L, Goletti D, Martineau AR, Lowe DM, Cronan MR,
• Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
• J Exp Med. (August 2021) doi:10.1084/jem.20210469
• PMID: 34347010

• COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge.
• DiPiazza AT, Leist SR, Abiona OM, Moliva JI, Werner A, Minai M, Nagata BM, Bock KW, Phung E, Schäfer A, Dinnon KH 3rd, Chang LA, Loomis RJ, Boyoglu-Barnum S, Alvarado GS, Sullivan NJ, Edwards DK, Morabito KM, Mascola JR, Carfi A, Corbett KS, Moore IN, Baric RS, Graham BS, Ruckwardt TJ.
• Immunity (July 2021) doi: 10.1016/j.immuni.2021.06.018.
• PMID: 34270939

• Short stature and combined immunodeficiency associated with mutations in RGS10
• Chinn IK, Xie Z, Chan EC, Nagata BM, Koval A, Chen WS, Zhang F, Ganesan S, Hong DN, Suzuki M, Nardone G, Moore IN, Katanaev VL, Balazs AE, Liu C, Lupski JR, Orange JS, Druey KM.
• Sci Signal. (July 2021) 27;14(693):eabc1940. doi: 10.1126/scisignal.abc1940.
• PMID: 34315806

• In vitro and in vivo functions of SARS-CoV-2 infection-enhancing and neutralizing antibodies
• Li D, Edwards RJ, Manne K, Martinez DR, Schäfer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin TH 3rd, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Von Holle T, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Rountree W, Wang Y, Moody MA, Cain DW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO.
• Cell (June 2021) doi: 10.1016/j.cell.2021.06.021.
• PMID: 34242577

• Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
• Saunders KO, Lee E, Parks R, Martinez DR, Li D, Chen H, Edwards RJ, Gobeil S, Barr M, Mansouri K, Alam SM, Sutherland LL, Cai F, Sanzone AM, Berry M, Manne K, Bock KW, Minai M, Nagata BM, Kapingidza AB, Azoitei M, Tse LV, Scobey TD, Spreng RL, Rountree RW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Tang J, Oguin TH 3rd, Sempowski GD, Gagne M, Douek DC, Tomai MA, Fox CB, Seder R, Wiehe K, Weissman D, Pardi N, Golding H, Khurana S, Acharya P, Andersen H, Lewis MG, Moore IN, Montefiori DC, Baric RS, Haynes BF.
• Nature. (May 2021). doi.org/10.1038/s41586-021-03594-0.
• PMID: 33971664

• Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis
• Nishimura N, De Battista D, McGivern DR, Engle RE, Tice A, Fares-Gusmao R, Kabat J, Pomerenke A, Nguyen H, Sato S, Bock KW, Moore IN, Kleiner DE, Zamboni F, Alter HJ, Govindarajan S, Farci P.
• Proc Natl Acad Sci USA. 118 (17) (April 2021): e2019633118. 10.1073/pnas.2019633118.
• PMID: 33888584

• Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques
• Sui Y, Li J, Zhang R, Prabhu SK, Elyard HA, Venzon D, Cook A, Brown RE, Teow E, Velasco J, Greenhouse J, Putmon-Taylor T, Campbell TV, Pessaint L, Moore IN, Lagenaur LA, Talton JD, Breed MW, Kramer J, Bock KW, Minai M, Nagata BM, Lewis MG, Wang LX, Berzofsky JA.
• JCI Insight. (April 2021): 148494. 10.1172/jci.insight.148494.
• PMID: 33908897

• Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses
• Maximova OA, Sturdevant DE, Kash JC, Kanakabandi K, Xiao Y, Minai M, Moore IN, Taubenberger J, Martens C, Cohen JI, Pletnev AG.
• Elife. 10 (e62273) (February 2021): 10.7554/eLife.62273.
• PMID: 33599611

• A Long-Acting Thermoresponsive Injectable Formulation of Tin Protoporphyrin Sustains Antitubercular Efficacy in a Murine Infection Model
• Adeleke OA, Fisher L, Moore IN, Nardone GA, Sher A.
• ACS Pharmacol Transl Sci. 4 (1) (December 2020): 276-287. 10.1021/acsptsci.0c00185.
• PMID: 33615179

• Heme Oxygenase-1 Induction by Blood-Feeding Arthropods Controls Skin Inflammation and Promotes Disease Tolerance
• DeSouza-Vieira T, Iniguez E, Serafim TD, de Castro W, Karmakar S, Disotuar MM, Cecilio P, Lacsina JR, Meneses C, Nagata BM, Cardoso S, Sonenshine DE, Moore IN, Borges VM, Dey R, Soares MP, Nakhasi HL, Oliveira F, Valenzuela JG, Kamhawi S.
• Cell Rep. 33 (4) (October 2020): 108317. 10.1016/j.celrep.2020.108317.
• PMID: 33113362

• SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
• Corbett KS, Edwards DK, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Wu K, Henry C, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Stevens LJ, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Alvarado GS, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness.
• Nature. 586 (7830) (October 2020): 567-571. 10.1038/s41586-020-2622-0.
• PMID: 32756549

• Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
• Corbett KS, Flynn B, Foulds KE, Francica JR, Boyoglu-Barnum S, Werner AP, Flach B, O'Connell S, Bock KW, Minai M, Nagata BM, Andersen H, Martinez DR, Noe AT, Douek N, Donaldson MM, Nji NN, Alvarado GS, Edwards DK, Flebbe DR, Lamb E, Doria-Rose NA, Lin BC, Louder MK, O'Dell S, Schmidt SD, Phung E, Chang LA, Yap C, Todd JM, Pessaint L, Van Ry A, Browne S, Greenhouse J, Putman-Taylor T, Strasbaugh A, Campbell TA, Cook A, Dodson A, Steingrebe K, Shi W, Zhang Y, Abiona OM, Wang L, Pegu A, Yang ES, Leung K, Zhou T, Teng IT, Widge A, Gordon I, Novik L, Gillespie RA, Loomis RJ, Moliva JI, Stewart-Jones G, Himansu S, Kong WP, Nason MC, Morabito KM, Ruckwardt TJ, Ledgerwood JE, Gaudinski MR, Kwong PD, Mascola JR, Carfi A, Lewis MG, Baric RS, McDermott A, Moore IN, Sullivan NJ, Roederer M, Seder RA, Graham BS.
• N Engl J Med. 383 (16) (October 2020): 1544-1555. 10.1056/NEJMoa2024671.
• PMID: 32722908

• Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair
• Myles IA, Castillo CR, Barbian KD, Kanakabandi K, Virtaneva K, Fitzmeyer E, Paneru M, Otaizo-Carrasquero F, Myers TG, Markowitz TE, Moore IN, Liu X, Ferrer M, Sakamachi Y, Garantziotis S, Swamydas M, Lionakis MS, Anderson ED, Earland NJ, Ganesan S, Sun AA, Bergerson JRE, Silverman RA, Petersen M, Martens CA, Datta SK.
• Sci Transl. Med. 12 (560) (September 2020): eaaz8631. 10.1126/scitranslmed.aaz8631.
• PMID: 32908007

• Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans.
• Chen Z, Engle RE, Shen CH, Zhao H, Schuck PW, Danoff EJ, Nguyen H, Nishimura N, Bock KW, Moore IN, Kwong PD, Purcell RH, Govindarajan S, Farci P.
• PLoS. Pathog. 16 (8) (August 2020): e1008793. 10.1371/journal.ppat.1008793.
• PMID: 32866189

• Alternaria alternata Accelerates Loss of Alveolar Macrophages and Promotes Lethal Influenza A Infection
• Percopo CM, Ma M, Mai E, Redes JL, Kraemer LS, Minai M, Moore IN, Druey KM, Rosenberg HF.
• Viruses. 12 (9) (August 2020): 946. 10.3390/v12090946.
• PMID: 32867061

• Human norovirus targets enteroendocrine epithelial cells in the small intestine
• Green KY, Kaufman SS, Nagata BM, Chaimongkol N, Kim DY, Levenson EA, Tin CM, Yardley AB, Johnson JA, Barletta ABF, Khan KM, Yazigi NA, Subramanian S, Moturi SR, Fishbein TM, Moore IN, Sosnovtsev SV.
• Nat Commun. 11 (1) (June 2020): 2759. 10.1038/s41467-020-16491-3.
• PMID: 32488028

• Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis
• Lewis MD, Paun A, Romano A, Langston H, Langner CA, Moore IN, Bock KW, Francisco AF, Brenchley JM, Sacks DL.
• PLoS Pathog. 16 (4) (April 2020): e1008456. 10.1371/journal.ppat.1008456.
• PMID: 32282850

• A primate model of severe malarial anaemia: a comparative pathogenesis study
• Raja AI, Brickley EB, Taaffe J, Ton T, Zhao Z, Bock KW, Orr-Gonzalez S, Thomas ML 3rd, Lambert LE, Moore IN, Duffy PE.
• Sci Rep. 9 (1) (December 2019): 18965. 10.1038/s41598-019-55377-3.
• PMID: 31831787

• Eosinophils Do Not Drive Acute Muscle Pathology in the mdx Mouse Model of Duchenne Muscular Dystrophy
• Sek AC, Moore IN, Smelkinson MG, Pak K, Minai M, Smith R, Ma M, Percopo CM, Rosenberg HF.
• J Immunol. 203 (2) (July 2019): 476-484. 10.4049/jimmunol.1900307.
• PMID: 31142604

• Differing Virulence of Healthy Skin Commensals in Mouse Models of Infection
• Myles IA, Moore IN, Castillo CR, Datta SK.
• Front Cell Infect Microbiol. 8 (January 2019): 451. 10.3389/fcimb.2018.00451.
• PMID: 30719426

• Clinical Characterization of Host Response to Simian Hemorrhagic Fever Virus Infection in Permissive and Refractory Hosts: A Model for Determining Mechanisms of VHF Pathogenesis
• Cornish JP, Moore IN, Perry DL, Lara A, Minai M, Promeneur D, Hagen KR, Virtaneva K, Paneru M, Buechler CR, O'Connor DH, Bailey AL, Cooper K, Mazur S, Bernbaum JG, Pettitt J, Jahrling PB, Kuhn JH, Johnson RF.
• Viruses. 11 (1) (January 2019): 67. 10.3390/v11010067.
• PMID: 30650570

• Coinfection With Trypanosoma brucei Confers Protection Against Cutaneous Leishmaniasis
• Pereira L, Oliveira F, Townsend S, Metangmo S, Meneses C, Moore IN, Brodskyn CI, Valenzuela JG, Magez S, Kamhawi S.
• Front Immunol. 9 (2855) (December 2018): 10.3389/fimmu.2018.02855.
• PMID: 30619253

• Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure
• Chen Z, Diaz G, Pollicino T, Zhao H, Engle RE, Schuck P, Shen CH, Zamboni F, Long Z, Kabat J, De Battista D, Bock KW, Moore IN, Wollenberg K, Soto C, Govindarajan S, Kwong PD, Kleiner DE, Purcell RH, Farci P.
• Proc Natl Acad Sci. 115 (48) (November 2018): e11369-e11378. 10.1073/pnas.1809028115.
• PMID: 30420516

• Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression
• Sallin M, Kauffman K, Riou C, Du Bruyn E, Foreman T, Sakai S, Hoft S, Myers T, Gardina P, Sher A, Moore R, Wilder-Kofie T, Moore I, Sette A, Lindestam Arlehamn C, Wilkinson R, Barber D.
• Nature Microbiology. 3 (11) (November 2018): 1198-1205. 10.1038/s41564-018-0231-6
• PMID: 30202016

• Limited Pulmonary Mucosal-Associated Invariant T Cell Accumulation and Activation during Mycobacterium tuberculosis Infection in Rhesus Macaques
• Kauffman KD, Sallin MA, Stella Hoft, Shunsuke Sakai, Rashida Moore, Temeri Wilder-Kofie, Moore IN, Alessandro Sette, Cecilia Lindestam Arleham, and l Barber DL.
• Infect Immun. 86 (12) (November 2018): e00431-18. 10.1128/IAI.00431-18.
• PMID: 30201702

• Prolonging culture of primary human keratinocytes isolated from suction blisters with the Rho kinase inhibitor Y-27632
• Anderson ED, Sastalla I, Earland NJ, Mahnaz M, Moore IN, Otaizo-Carrasquero F, Myers TG, Myles CA, Datta SK, Myles IA
• PLos One. 13 (9) (September 2018): e0198862. 10.1371/journal.pone.0198862.
• PMID: 30208113

• Molecular Signature and Mechanisms of Hepatitis D Virus-Associated Hepatocellular Carcinoma
• Diaz G, Engle RE, Tice A, Melis M, Montenegro S, Rodriguez-Canales J, Hanson J, Emmert-Buck MR, Bock KW, Moore IN, Zamboni F, Govindarajan S, Kleiner DE, Farci P.
• Mol Cancer Res. 16 (9) (September 2018): 1406-1419. 10.1158/1541-7786.MCR-18-0012.
• PMID: 29858376

• TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome
• Myles IA, Anderson ED, Earland NJ, Zarember KA, Sastalla I, Williams KW, Gough P, Moore IN, Ganesan S, Fowler CJ, Laurence A, Garofalo M, Kuhns DB, Kieh MD, Saleem A, Welch PA, Darnell DA, Gallin JI, Freeman AF, Holland SM, Datta SK.
• J Clin Invest. 128 (8) (August 2018): 3595-3604. 10.1172/JCI121486.
• PMID: 30035749

• A spike-modified Middle East respiratory syndrome coronavirus (MERS-CoV) infectious clone elicits mild respiratory disease in infected rhesus macaques
• Cockrell AS, Johnson JC, Moore IN, Liu DX, Bock KW, Douglas MG, Graham RL, Solomon J, Torzewski L, Bartos C, Hart R, Baric RS, Johnson RF.
• Sci Rep. 8 (1) (July 2018): 10727. 10.1038/s41598-018-28900-1
• PMID: 30013082

• Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection
• Martin-Martin I, Chagas AC, Guimaraes-Costa AB, Amo L, Oliveira F, Moore IN, DeSouza-Vieira TS, Sanchez EE, Suntravat M, Valenzuela JG, Ribeiro JMC, Calvo E.
• PLoS Pathog. 14 (5) (May 2018): e1007006. 10.1371/journal.ppat.1007006.
• PMID: 29723281

• First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis
• Myles IA, Earland NJ, Anderson ED, Moore IN, Kieh MD, Williams KW, Saleem A, Fontecilla NM, Welch PA, Darnell DA, Barnhart LA, Sun AA, Uzel G, Datta SK.
• JCI Insight. 3 (9) (May 2018): e120608. 10.1172/jci.insight.120608.
• PMID: 29720571

• Ticks, Ixodes scapularis, Feed Repeatedly on White-Footed Mice despite Strong Inflammatory Response: An Expanding Paradigm for Understanding Tick-Host Interactions
• Anderson JM, Moore IN, Nagata BM, Ribeiro JMC, Valenzuela JG, Sonenshine DE.
• Front Immunol. 8 (1784) (December 2017): 10.3389/fimmu.2017.01784.
• PMID: 29326693

• Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines
• Sutton TC, Chakraborty S, Mallajosyula VVA, Lamirande EW, Ganti K, Bock KW, Moore IN, Varadarajan R, Subbarao K.
• NPJ Vaccines. 2 (35) (December 2017): 10.1038/s41541-017-0036-2.
• PMID: 29263889

• In Vitro Neutralization Is Not Predictive of Prophylactic Efficacy of Broadly Neutralizing Monoclonal Antibodies CR6261 and CR9114 against Lethal H2 Influenza Virus Challenge in Mice
• Sutton TC, Lamirande EW, Bock KW, Moore IN, Koudstaal W, Rehman M, Weverling GJ, Goudsmit J, Subbarao K.
• J Virol. 91 (24) (November 2017): e01603-17. 10.1128/JVI.01603-17.
• PMID: 29046448

• Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model
• Lacerda-Queiroz N, Riteau N, Eastman RT, Bock KW, Orandle MS, Moore IN, Sher A, Long CA, Jankovic D, Su XZ.
• Sci Rep. 7 91) (September 2017): 10438. 10.1038/s41598-017-10776-2.
• PMID: 28874800

• Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques
• Kauffman KD, Sallin MA, Sakai S, Kamenyeva O, Kabat J, Weiner D, Sutphin M, Schimel D, Via L, Barry CE 3rd, Wilder-Kofie T, Moore I, Moore R, Barber DL.
• Mucosal Immunol. 11 (2) (March 2018): 462-473. 10.1038/mi.2017.60.
• PMID: 28745326

• Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses
• Boonnak K, Matsuoka Y, Wang W, Suguitan AL Jr, Chen Z, Paskel M, Baz M, Moore I, Jin H, Subbarao K.
• J. Virol. 91 (15) (July 2017): e00547-17. 10.1128/JVI.00547-17.
• PMID: 28490598

• Enhanced inflammation in New Zealand white rabbits when MERS-CoV reinfection occurs in the absence of neutralizing antibody
• Houser KV, Broadbent AJ, Gretebeck L, Vogel L, Lamirande EW, Sutton T, Bock KW, Minai M, Orandle M, Moore IN, Subbarao K.
• PLoS Pathog. 13 (8) (August 2017): e1006565. 10.1371/journal.ppat.1006565.
• PMID: 28817732

• In Vivo Imaging of Influenza Virus Infection in Immunized Mice
• Czakó R, Vogel L, Lamirande EW, Bock KW, Moore IN, Ellebedy AH, Ahmed R, Mehle A, Subbarao K.
• MBio. 8 (3) (May 2017): e00714-17. 10.1128/mBio.00714-17.
• PMID: 28559489

• Lethal CD4 T Cell Responses Induced by Vaccination Against Staphylococcus aureus Bacteremia
• Karauzum H, Haudenschild CC, Moore IN, Mahmoudieh M, Barber DL, Datta SK.
• J Infect Dis. 215 (8) (April 2017): 1231-1239. 10.1093/infdis/jix096.
• PMID: 28329242

• Infection of Hysterectomized Mice with Chlamydia muridarum and Chlamydia trachomatis
• Yang C, Whitmire WM, Sturdevant GL, Bock K, Moore I, Caldwell HD.
• Infect Immun. 85 (7) (June 2017): e00197-17. 10.1128/IAI.00197-17.
• PMID: 28461392

• A homolog of the variola virus B22 membrane protein contributes to ectromelia virus pathogenicity in the mouse footpad model
• Reynolds SE, Earl PL, Minai M, Moore I, Moss B.
• Virology. 501 (January 2017): 107-114. 10.1016/j.virol.2016.11.010.
• PMID: 27898336

• Acidic chitinase primes the protective immune response to gastrointestinal nematodes
• Vannella KM, Ramalingam TR, Hart KM, de Queiroz Prado R, Sciurba J, Barron L, Borthwick LA, Smith AD, Mentink-Kane M, White S, Thompson RW, Cheever AW, Bock K, Moore I, Fitz LJ, Urban JF Jr, Wynn TA.
• Nat Immunol. 17 (5) (May 2016): 538-44. 10.1038/ni.3417.
• PMID: 27043413

• Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection
• Houser KV, Gretebeck L, Ying T, Wang Y, Vogel L, Lamirande EW, Bock KW, Moore IN, Dimitrov DS, Subbarao K.
• J Infect Dis. 213 (10) (May 2016): 1557-61. 10.1093/infdis/jiw080.
• PMID: 26941283

• Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease
• Johnson RF, Hammoud DA, Perry DL, Solomon J, Moore IN, Lackemeyer MG, Bohannon JK, Sayre PJ, Minai M, Papaneri AB, Hagen KR, Janosko KB, Jett C, Cooper K, Blaney JE, Jahrling PB.
• J Gen Virol. 97 (8) (August 2016):1942-1954. 10.1099/jgv.0.000501.
• PMID: 27166137

• The soft palate is an important site of adaptation for transmissible influenza viruses
• Lakdawala SS, Jayaraman A, Halpin RA, Lamirande EW, Shih AR, Stockwell TB, Lin X, Simenauer A, Hanson CT, Vogel L, Paskel M, Minai M, Moore I, Orandle M, Das SR, Wentworth DE, Sasisekharan R, Subbarao K.
• Nature. 526 (7571) (October 2015): 122-5. 10.1038/nature15379.
• PMID: 26416728

• Severity of clinical disease and pathology in ferrets experimentally infected with influenza viruses is influenced by inoculum volume
• Moore, IN, Lamirande EW, Paskel, M, Donahue D, Qin J, Subbarao, K.
• J Virol. 88 (23) (December 2014): 13879-91. 10.1128/JVI.02341-14.
• PMID: 25187553

• Enteric colonization by staphylococcus delphini in four ferret kits with diarrhoea
• Gary JM, Langohr IM, Lim A, Bolin S, Bolin C, Moore I, Kiupel M.
• J Comp Pathol. 151 (4) (November 2014): 314-7. 10.1016/j.jcpa.2014.08.004.
• PMID: 25246181

• Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets
• Lakdawala, S., Shih, A., Jayaraman, A., Lamirande, E., Moore, I., Paskel, M., Sasisekharan, R., Subbarao, K.
• J Virol. 446 (1-2) (November 2013): 349-56. 10.1016/j.virol.2013.08.011.
• PMID: 24074599

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Jessica Beck, D.V.M., Ph.D.

• Diplomate, ACVP
• PROGRAM GRADUATE 2020

• Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.
• Puri M, Hoover SB, Hewitt SM, Wei BR, Adissu HA, Halsey CHC, Beck J, Bradley C, Cramer SD, Durham AC, Esplin DG, Frank C, Lyle LT, McGill LD, Sánchez MD, Schaffer PA, Traslavina RP, Buza E, Yang HH, Lee MP, Dwyer JE, Simpson RM.
• J Pathol Inform. 2019 Feb 7;10:4. doi: 10.4103/jpi.jpi_59_18. eCollection 2019.
• PMID: 30915258

• Radiation-induced astrocyte senescence is rescued by Δ133p53.
• Turnquist C, Beck JA, Horikawa I, Obiorah IE, von Muhlinen N, Vojtesek B, Lane DP, Grunseich C, Chahine JJ, Ames HM, Smart D, Harris BT, Harris CC.
• Neuro Oncol. 2019 Jan 4. doi: 10.1093/neuonc/noz001.
• PMID: 30615147

• A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.
• Koehler JW, Miller AD, Miller CR, Porter B, Aldape K, Beck J, Brat D, Cornax I, Corps K, Frank C, Giannini C, Horbinski C, Huse JT, O'Sullivan MG, Rissi DR, Mark Simpson R, Woolard K, Shih JH, Mazcko C, Gilbert MR, LeBlanc AK.
• J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1039-1054. doi: 10.1093/jnen/nly085.
• PMID: 30239918

• Interaction between the microbiome and TP53 in human lung cancer.
• Greathouse KL, White JR, Vargas AJ, Bliskovsky VV, Beck JA, von Muhlinen N, Polley EC, Bowman ED, Khan MA, Robles AI, Cooks T, Ryan BM, Padgett N, Dzutsev AH, Trinchieri G, Pineda MA, Bilke S, Meltzer PS, Hokenstad AN, Stickrod TM, Walther-Antonio MR, Earl JP, Mell JC, Krol JE, Balashov SV, Bhat AS, Ehrlich GD, Valm A, Deming C, Conlan S, Oh J, Segre JA, Harris CC.
• Genome Biol. 2018 Aug 24;19(1):123. doi: 10.1186/s13059-018-1501-6.
• PMID: 30143034

• HOXA9 methylation and blood vessel invasion in FFPE tissues for prognostic stratification of stage I lung adenocarcinoma patients.
• Lissa D, Ishigame T, Noro R, Tucker MJ, Bliskovsky V, Shema S, Beck JA, Bowman ED, Harris CC, Robles AI.
• Lung Cancer. 2018 Aug;122:151-159. doi: 10.1016/j.lungcan.2018.05.021. Epub 2018 May 22.
• PMID: 30032824

• Surfactant Protein A and Napsin A in the Immunohistochemical Characterization of Canine Pulmonary Carcinomas: Comparison With Thyroid Transcription Factor-1.
• Beck J, Miller MA, Frank C, DuSold D, Ramos-Vara JA.
• Vet Pathol. 2017 Sep;54(5):767-774. doi: 10.1177/0300985817712559. Epub 2017 Jun 5.
• PMID: 28578631

• Agreement in Histological Asessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.
• Wei BR, Halsey CH, Hoover SB, Puri M, Yang HH, Gallas BD, Lee MP, Chen W, Durham AC, Dwyer JE, Sanchez MD, Translavina RP, Frank C, Bradley C, McGill LD, Esplin DG, Schaffer PA, Cramer SD, Lyle LT, Beck J, Buza E, Gong Q, Hewitt SM, Simpson RM.
• Acadmic Pathology July 2019; doi: 10.1177/2374289519859841.
• PMID: 31321298

• Glutaminase-1 (GLS1) inhibition limits metastatic progression in Osteosarcoma.
• Ren L, Ruiz-Rodado V, Dowdy T, Huang S, Issaq SH, Beck J, Wang H, Tran Hoang C, Lita A, Larlon M, LeBlanc AK.
• Cancer Metabolism, March 2020; doi:10.1186/s40170-020-0209-8.
• PMID: 32158544

• Cellular Senescence: Mechanisms, Morphology, and Mouse Models.
• Beck J, Horikawa I, Harris C.
• Vet Pathol. 2020 Nov;57(6):747-757. doi: 10.1177/0300985820943841. Epub 2020 Aug 3.
• PMID: 32744147

• Targeting cellular senescence in cancer and aging: roles of p53 and its isoforms. Carcinogenesis.
• Beck J, Turnquist C, Horikawa I, Harris C.
• 2020 Aug 12;41(8):1017-1029. doi: 10.1093/carcin/bgaa071.
• PMID: 32619002

• Diagnosis of Collagen Type III Glomerulopathy Using Picrosirius Red and PASH/Masson's Trichrome Stain.
• Davis KL, Burnum AL, Beck JA, Kirejczyk SGM, Miller MA, Sola MF, Brown CA.
• Vet Pathol. 2020 Sep;57(5):675-680. doi: 10.1177/0300985820934111. Epub 2020 Jun 17.
• PMID: 32880237

• The Δ133p53 Isoforms, Tuners of the p53 Pathway.
• Joruiz SM, Beck JA, Horikawa I, Harris CC.
• Cancers (Basel). 2020 Nov 18;12(11):3422. doi: 10.3390/cancers12113422.
• PMID: 33218139

• Astrocyte senescence and SASP in neurodegeneration: tau joins the loop.
• Ungerleider K, Beck J, Lissa D, Turnquist C, Horikawa I, Harris BT, Harris CC.
• Cell Cycle. 2021 Apr;20(8):752-764. doi: 10.1080/15384101.2021.1909260. Epub 2021 Apr 5.
• PMID: 33818291

• EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells.
• Miyanaga A, Matsumoto M, Beck JA, Horikawa I, Oike T, Okayama H, Tanaka H, Burkett SS, Robles AI, Khan M, Lissa D, Seike M, Gemma A, Mano H, Harris CC.
• BMC Cancer. 2021 Mar 24;21(1):310. doi: 10.1186/s12885-021-07905-6.
• PMID: 33761896

• What is your diagnosis? An endotracheal wash from a dyspneic 3-month-old female Labrador Retriever.
• Camus M, Cazzini P, Beck J, Bugbee A.
• Vet Clin Pathol. 2013 Dec;42(4):527-8. doi: 10.1111/vcp.12076. Epub 2013 Sep 13.
• PMID:

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Joy Gary, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2015

• Enteric Colonization by Staphylococcus delphini in Four Ferret Kits with Diarrhoea.
• Gary JM, Langohr IM, Lim A, Bolin S, Bolin C, Moore I, Kiupel M.
• J Comp Pathol. 2014 Nov;151(4):314-7. doi: 10.1016/j.jcpa.2014.08.004. Epub 2014 Sep 22.
• PMID: 25246181

• Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
• Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM
• Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.
• PMID: 24128326

• B cell-specific deficiencies in mTOR limit humoral immune responses.
• Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.
• J Immunol. 2013 Aug 15;191(4):1692-703. doi: 10.4049/jimmunol.1201767. Epub 2013 Jul 15.
• PMID: 23858034

• T cell rich, B cell lymphoma in the small colon of a yearling horse.
• Smith KM, Clark CK, Kiupel M, Gary J.
• Equine Veterinary Education. 2012 March 28. Advance online publication.
• PMID:

• Medium-grade astrocytoma in a cougar (Puma concolor).
• Kondo H, Leone AM, Erlacher-Reid C, Gary J, Kiupel M, Farina LL, Abbott JR.
• J Zoo Wildl Med. 2012 Dec;43(4):956-60.
• PMID: 23272372

• http://www.ncbi.nlm.nih.gov/pubmed/18607345
• Wood CE, Hester JM, Appt SE, Geisinger KR, Cline JM.
• Lab Invest. 2008 Sep;88(9):938-48. doi: 10.1038/labinvest.2008.64. Epub 2008 Jul 7.
• PMID: 18607345

• Effects of relocation on movements and home ranges of eastern box turtles (Terrapene carolina).
• Hester JM, Price SJ, and Dorcas ME
• Journal of Wildlife Management. 2008; 72 (3): 772-777.
• PMID:

• The Davidson College Box Turtle Mark-Recapture Program: Urban Herpetological Research Made Possible by Citizen Scientists.
• Hester JM, Budischak SA, and Dorcas ME.
• In R. E. Jung and J. C. Mitchell (eds.), Urban Herpetology. Herpetological Conservation Vol. 3, Society for the Study of Amphibians and Reptiles. 2008; Salt Lake City, UT.
• PMID:

• Mammary gland development in early pubertal female macaques.
• Wood CE, Hester JM, and Cline JM.
• Toxicol Pathol. 2007 Oct;35(6):795-805.
• PMID: 17943653

• Natural history of box turtles, Terrapene carolina, in an urbanized landscape.
• Budischak SA, Hester JM, Price SJ, and Dorcas ME.
• Southeastern Naturalist. 2006; 5:191-204.
• PMID:

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Kara Corps, M.S., D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2018

• A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.
• Koehler JW, Miller AD, Miller CR, Porter B, Aldape K, Beck J, Brat D, Cornax I, Corps K, Frank C, Giannini C, Horbinski C, Huse JT, O'Sullivan MG, Rissi DR, Mark Simpson R, Woolard K, Shih JH, Mazcko C, Gilbert MR, LeBlanc AK.
• J Neuropathol Exp Neurol. 2018 Nov 1;77(11):1039-1054. doi: 10.1093/jnen/nly085.
• PMID: 30239918

• Inflammation and Neuroprotection in Traumatic Brain Injury.
• Corps KN, Roth TL, McGavern DB.
• JAMA Neurol. 2015 Jan 19. doi: 10.1001/jamaneurol.2014.3558.
• PMID: 25599342

• Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.
• LeBlanc AK, Mazcko C, Brown DE, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine JM, Simpson RM, Halsey C, Kisseberth W, Rossmeisl JH Jr, Dickinson PJ, Fan TM, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR.
• Neuro Oncol. 2016 Sep;18(9):1209-18. doi: 10.1093/neuonc/now051. Epub 2016 May 14. Review.
• PMID: 27179361

• In vivo dynamics of innate immune sentinels in the CNS.
• Nayak D, Zinselmeyer B, Corps K, McGavern D
• Intravital 2012; 1:2, 95-106.
• PMID:

• Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis.
• Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM.
• J Pathol Inform. 2012;3:18. doi: 10.4103/2153-3539.95130. Epub 2012 Apr 18.
• PMID: 22616030

• Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury.
• Corps KN, Islam Z, Pestka JJ, Harkema JR.
• Toxicol Pathol. 2010;38(3):429-51.
• PMID: 20430879

• Veterinarians in biomedical research: building national capacity.
• Buss DD, Atchison ML, Corps KN, Falkowski LB, Fox JG, Hendricks JC, Mexas AM, Rosol TJ, Stromberg BE.
• J Vet Med Educ. 2009 Spring;36(1):62-9.
• PMID: 19435991

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Kevin Woolard, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2010

• Identification of molecular pathways facilitating glioma cell invasion in situ.
• Nevo I, Woolard K, Cam M, Li A, Webster JD, Kotliarov Y, Kim HS, Ahn S, Walling J, Kotliarova S, Belova G, Song H, Bailey R, Zhang W, Fine HA.
• PLoS One. 2014 Nov 3;9(11):e111783. doi: 10.1371/journal.pone.0111783. eCollection 2014.
• PMID: 25365423

• Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells.
• Baysan M, Woolard K, Bozdag S, Riddick G, Kotliarova S, Cam MC, Belova GI, Ahn S, Zhang W, Song H, Walling J, Stevenson H, Meltzer P, Fine HA.
• PLoS One. 2014 Apr 11;9(4):e94045. doi: 10.1371/journal.pone.0094045. eCollection 2014.
• PMID: 24728236

• ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.
• Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG.
• Cell Rep. 2014 Jan 30;6(2):313-24. doi: 10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16.
• PMID: 24440720

• Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.
• Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, Lai C, Belova G, Cam M, Walling J, Zhou M, Stevenson H, Kim HS, Killian K, Veenstra T, Bailey R, Song H, Zhang W, Fine HA.
• PLoS One. 2012;7(12):e51407. doi: 10.1371/journal.pone.0051407. Epub 2012 Dec 7.
• PMID: 23236496

• Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.
• Kim HS, Woolard K, Lai C, Bauer PO, Maric D, Song H, Li A, Kotliarova S, Zhang W, Fine HA.
• Cancer Res. 2012 Nov 15;72(22):6065-75. doi: 10.1158/0008-5472.CAN-12-2594. Epub 2012 Sep 17.
• PMID: 22986743

• Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma.
• Morgan RA, Johnson LA, Davis JL, Zheng Z, Woolard KD, Reap EA, Feldman SA, Chinnasamy N, Kuan CT, Song H, Zhang W, Fine HA, Rosenberg SA.
• Hum Gene Ther. 2012 Oct;23(10):1043-53. doi: 10.1089/hum.2012.041. Epub 2012 Sep 24.
• PMID: 22780919

• Science & Alumni CBSTP Alumni Science & Publications Home• Science & Alumni • Science & Publications Science & Publications Graduate Publications Laura Baseler (2015 Graduate) Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With
• Edwards LA, Woolard K, Son MJ, Li A, Lee J, Ene C, Mantey SA, Maric D, Song H, Belova G, Jensen RT, Zhang W, Fine HA.
• J Natl Cancer Inst. 2011 Aug 3;103(15):1162-78. doi: 10.1093/jnci/djr224. Epub 2011 Jul 19.
• PMID: 21771732

• Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.
• Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI, Alvord WG, Quinones OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM, Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA, Petricoin EF, Simpson RM.
• PLoS One. 2009 Oct 30;4(10):e7670.
• PMID: 19888321

• Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice
• Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.
• Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. Epub 2009 Aug 10.
• PMID: 19667175

• Glioma stem cells: better flat than round.
• Woolard K, Fine HA.
• Cell Stem Cell. 2009 Jun 5;4(6):466-7.
• PMID: 19497271

• SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma.
• Son MJ, Woolard K, Nam DH, Lee J, Fine HA.
• Cell Stem Cell. 2009 May 8;4(5):440-52.
• PMID: 19427293

• Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
• Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA.
• Cancer Cell. 2008 Jan;13(1):69-80.
• PMID: 18167341

• Clearance of a dermal Huffmanela sp. in a sandbar shark (Carcharhinus plumbeus) using levamisole.
• MacLean RA, Fatzinger MH, Woolard KD, Harms CA.
• Dis Aquat Organ. 2006 Nov 21;73(1):83-8.
• PMID: 17240757

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Laura Baseler, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2015

• Identifying Early Target Cells of Nipah Virus Infection in Syrian Hamsters.
• Baseler L, Scott DP, Saturday G, Horne E, Rosenke R, Thomas T, Meade-White K, Haddock E, Feldmann H, de Wit E.
• PLoS Negl Trop Dis. 2016 Nov 3;10(11):e0005120. doi: 10.1371/journal.pntd.0005120. eCollection 2016 Nov.
• PMID: 27812087

• An Acute Immune Response to Middle East Respiratory Syndrome Coronavirus Replication Contributes to Viral Pathogenicity.
• Baseler LJ, Falzarano D, Scott DP, Rosenke R, Thomas T, Munster VJ, Feldmann H, de Wit E.
• Am J Pathol. 2016 Mar;186(3):630-8. doi: 10.1016/j.ajpath.2015.10.025. Epub 2015 Dec 24.
• PMID: 26724387

• Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With a Nipah Virus Isolate From Bangladesh or Malaysia Develop Similar Respiratory Tract Lesions.
• Baseler L, de Wit E, Scott DP, Munster VJ, Feldmann H.
• Vet Pathol. 2015 Jan;52(1):38-45. doi: 10.1177/0300985814556189. Epub 2014 Oct 28.
• PMID: 25352203

• Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques.
• Falzarano D, de Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, Brining D, Bushmaker T, Martellaro C, Baseler L, Benecke AG, Katze MG, Munster VJ, Feldmann H.
• Nat Med. 2013 Oct;19(10):1313-7. doi: 10.1038/nm.3362. Epub 2013 Sep 8.
• PMID: 24013700

• The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.
• de Wit E, Prescott J, Baseler L, Bushmaker T, Thomas T, Lackemeyer MG, Martellaro C, Milne-Price S, Haddock E, Haagmans BL, Feldmann H, Munster VJ.
• PLoS One. 2013 Jul 2;8(7):e69127. doi: 10.1371/journal.pone.0069127. Print 2013.
• PMID: 23844250

• Arsenic toxicosis in cattle: meta-analysis of 156 cases.
• Bertin FR, Baseler LJ, Wilson CR, Kritchevsky JE, Taylor SD.
• J Vet Intern Med. 2013 Jul-Aug;27(4):977-81. doi: 10.1111/jvim.12124. Epub 2013 Jun 12. Review.
• PMID: 23758199

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Leah Zadrozny, D.V.M., Ph.D.

• Program Graduate 2015

• Study of the Development of the Mouse Thoracic Aorta Three-Dimensional Macromolecular Structure using Two-Photon Microscopy.
• Zadrozny LM, Neufeld EB, Lucotte BM, Connelly PS, Yu ZX, Dao L, Hsu LY, Balaban RS.
• J Histochem Cytochem. 2015 Jan;63(1):8-21. doi: 10.1369/0022155414559590. Epub 2014 Oct 31.
• PMID: 25362141

• Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.
• Neufeld EB, Zadrozny LM, Phillips D, Aponte A, Yu ZX, Balaban RS.
• Atherosclerosis. 2014 Mar;233(1):113-21. doi: 10.1016/j.atherosclerosis.2013.12.038. Epub 2014 Jan 8.
• PMID: 24529131

• Spontaneous hepatocellular carcinoma in captive prosimians.
• Zadrozny LM, Williams CV, Remick AK, Cullen JM.
• Vet Pathol. 2010 Mar;47(2):306-11. Epub 2009 Dec 31.
• PMID: 20147584

• 5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats.
• Elangbam CS, Job LE, Zadrozny LM, Barton JC, Yoon LW, Gates LD, Slocum N.
• Exp Toxicol Pathol. 2008 Aug;60(4-5):253-62. Epub 2008 Jun 3.
• PMID: 18511249

• Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets.
• Zadrozny LM, Stauffer SH, Armstrong MU, Jones SL, Gookin JL.
• Infect Immun. 2006 Oct;74(10):5497-505.
• PMID: 16988224

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Mark J. Hoenerhoff, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2008

• Capacity for resolution of Ras-MAPK-initiated early pathogenic myocardial hypertrophy modeled in mice.
• Wei BR, Martin PL, Hoover SB, Spehalski E, Kumar M, Hoenerhoff MJ, Rozenberg J, Vinson C, Simpson RM.
• Comp Med. 2011 Apr;61(2):109-18.
• PMID: 21535921

• Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer.
• Hoenerhoff MJ, Shibata MA, Bode A, Green JE.
• Transgenic Res. 2010 Jun 12. [Epub ahead of print]
• PMID: 20549348

• BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
• Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE.
• Oncogene. 2009 Aug 27;28(34):3022-32. Epub 2009 Jun 22.
• PMID: 19543317

• Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.
• Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP.
• Cancer Res. 2007 Nov 1;67(21):10286-95.
• PMID: 17974970

• Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis.
• Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE.
• Cancer Res. 2007 Sep 1;67(17):8065-80. Erratum in: Cancer Res. 2007 Oct 15;67(20):10097.
• PMID: 17804718

• Fatal herpesvirus encephalitis in a reticulated giraffe (Giraffa camelopardalis reticulata).
• Hoenerhoff MJ, Janovitz EB, Richman LK, Murphy DA, Butler TC, Kiupel M.
• Vet Pathol. 2006 Sep;43(5):769-72.
• PMID: 16966458

• Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice.
• Hoenerhoff MJ, Starost MF, Ward JM.
• Vet Pathol. 2006 Sep;43(5):682-8.
• PMID: 16966445

• Choroid plexus papilloma in a Scottish highland cow.
• Hoenerhoff MJ, Janovitz E, Ramos-Vara J, Kiupel M.
• J Comp Pathol. 2006 Aug-Oct;135(2-3):146-9. Epub 2006 Sep 6.
• PMID: 16952368

• Multipotential osteosarcoma with various mesenchymal differentiations in a young dog.
• Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR.
• Vet Pathol. 2004 May;41(3):264-8.
• PMID: 15133175

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Philip Martin, M.S., D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2014

• Androgen deprivation leads to increased carbohydrate metabolism and hexokinase 2-mediated survival in Pten/Tp53-deficient prostate cancer.
• Martin PL, Yin JJ, Seng V, Casey O, Corey E, Morrissey C, Simpson RM, Kelly K.
• Oncogene. 2017 Jan 26;36(4):525-533. doi: 10.1038/onc.2016.223. Epub 2016 Jul 4.
• PMID: 27375016

• "Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.
• Day CP, Carter J, Weaver Ohler Z, Bonomi C, El Meskini R, Martin P, Graff-Cherry C, Feigenbaum L, Tüting T, Van Dyke T, Hollingshead M, Merlino G.
• PLoS One. 2014 Nov 4;9(11):e109956. doi: 10.1371/journal.pone.0109956. eCollection 2014.
• PMID: 25369133

• Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.
• Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM.
• Cell. 2014 Sep 25;159(1):80-93. doi: 10.1016/j.cell.2014.08.007.
• PMID: 25259922

• Science & Alumni CBSTP Alumni Science & Publications Home• Science & Alumni • Science & Publications Science & Publications Graduate Publications Laura Baseler (2015 Graduate) Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With
• Szabova L, Bupp S, Kamal M, Householder DB, Hernandez L, Schlomer JJ, Baran ML, Yi M, Stephens RM, Annunziata CM, Martin PL, Van Dyke TA, Weaver Ohler Z, Difilippantonio S.
• PLoS One. 2014 Apr 18;9(4):e95649. doi: 10.1371/journal.pone.0095649. eCollection 2014.
• PMID: 24748377

• Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.
• Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, Simons BW, Ward JM, Robinson BD, Chu GC, Loda M, Thomas G, Borowsky A, Cardiff RD.
• Cancer Res. 2013 May 1;73(9):2718-36. doi: 10.1158/0008-5472.CAN-12-4213. Epub 2013 Apr 22.
• PMID: 23610450

• Carcinoma Initiation via Rb Tumor Suppressor Inactivation: A Versatile Approach to Epithelial Subtype-Dependent Cancer Initiation in Diverse Tissues.
• Song Y, Gilbert D, O'Sullivan TN, Yang C, Pan W, Fathalizadeh A, Lu L, Haines DC, Martin PL, Van Dyke T.
• PLoS One. 2013 Dec 2;8(12):e80459. doi: 10.1371/journal.pone.0080459. eCollection 2013.
• PMID: 24312475

• MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
• Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
• Oncogene. 2013 Jan 17;32(3):296-306. doi: 10.1038/onc.2012.58. Epub 2012 Feb 27.
• PMID: 22370643

• Science & Alumni CBSTP Alumni Science & Publications Home• Science & Alumni • Science & Publications Science & Publications Graduate Publications Laura Baseler (2015 Graduate) Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With
• Weaver Z, Difilippantonio S, Carretero J, Martin PL, El Meskini R, Iacovelli AJ, Gumprecht M, Kulaga A, Guerin T, Schlomer J, Baran M, Kozlov S, McCann T, Mena S, Al-Shahrour F, Alexander D, Wong KK, Van Dyke T.
• Cancer Res. 2012 Nov 15;72(22):5921-33. doi: 10.1158/0008-5472.CAN-12-0736. Epub 2012 Sep 11.
• PMID: 22969147

• TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.
• Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.
• PLoS One. 2012;7(7):e41668. doi: 10.1371/journal.pone.0041668. Epub 2012 Jul 30.
• PMID: 22860005

• CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.
• Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K.
• Oncogene. 2013 May 30;32(22):2726-38. doi: 10.1038/onc.2012.301. Epub 2012 Jul 16
• PMID: 22797060

• Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.
• Szabova L, Yin C, Bupp S, Guerin TM, Schlomer JJ, Householder DB, Baran ML, Yi M, Song Y, Sun W, McDunn JE, Martin PL, Van Dyke T, Difilippantonio S.
• Cancer Res. 2012 Aug 15;72(16):4141-53. doi: 10.1158/0008-5472.CAN-11-3834. Epub 2012 May 22.
• PMID: 22617326

• Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.
• Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
• Mol Cell Biol. 2012 Mar;32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27.
• PMID: 22203039

• Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.
• Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V, Lake R, Spurrier J, Kelly K.
• PLoS One. 2011;6(10):e26112. doi: 10.1371/journal.pone.0026112. Epub 2011 Oct 11.
• PMID: 22022528

• Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model.
• Kimble JB, Sorrell E, Shao H, Martin PL, Perez DR.
• Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12084-8. doi: 10.1073/pnas.1108058108. Epub 2011,Jul 5.
• PMID: 21730147

• Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.
• Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V, Camacho D, Simpson RM, Kelly K.
• Am J Pathol. 2011 Jul;179(1):422-35. doi: 10.1016/j.ajpath.2011.03.035. Epub 2011 May 13.
• PMID: 21703421

• Science & Alumni CBSTP Alumni Science & Publications Home• Science & Alumni • Science & Publications Science & Publications Graduate Publications Laura Baseler (2015 Graduate) Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With
• Wei BR, Martin PL, Hoover SB, Spehalski E, Kumar M, Hoenerhoff MJ, Rozenberg J, Vinson C, Simpson RM.
• Comp Med. 2011 Apr;61(2):109-18.
• PMID: 21535921

• Characterizing the Contribution of Stem/Progenitor Cells to Tumorigenesis in the Pten(-/-)TP53(-/-) Prostate Cancer Model.
• Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K.
• Stem Cells. 2010 Oct 8.
• PMID: 20936707

• Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.
• Yin J, Pollock C, Tracy K, Chock M, Martin P, Oberst M, Kelly K.
• Mol Cell Biol. 2007 Nov;27(21):7538-50. Epub 2007 Aug 20.
• PMID: 17709381

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Raisa Glabman, M.S., V.M.D.

• Diplomate, ACVP
• Program Graduate 2023

• Proportional loss of parvalbumin-immunoreactive synaptic boutons and granule cells from the hippocampus of sea lions with temporal lobe epilepsy.
• Cameron S, Lopez A, Glabman R, Abrams E, Johnson S, Field C, Gulland FMD, Buckmaster PS.
• J Comp Neurol. 2019 Mar 12. doi: 10.1002/cne.24680.
• PMID: 30861128

• Evaluation of the Filum Terminale in Hereditary Equine Regional Dermal Asthenia.
• McElroy A, Klinge PM, Sledge D, Donahue JE, Glabman RA, Rashmir A.
• Vet Pathol. 2021 May 31:3009858211018660. doi: 10.1177/03009858211018660. Epub ahead of print.
• PMID: 340569

• Atypical Brucella inopinata-Like Species in 2 Marine Toads.
• Glabman RA, Thompson KA, Mani R, Colburn R, Agnew DW.
• Emerg Infect Dis. 2021 Jun;27(6):1748-1750.
• PMID:

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Sarah Cramer, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2017

• Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.
• Cramer SD, Aplan PD, Durum SK.
• Blood. 2016 Jul 28;128(4):473-8. doi: 10.1182/blood-2016-03-679209. Epub 2016 Jun 6. Review.
• PMID: 27268088

• Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.
• Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.
• Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.
• PMID: 24264989

• Chapter 25: Pseudorabies.
• SD Cramer.
• In JE Sykes, editor, Canine and Feline Infectious Diseases. Elsevier, St. Louis, MO, 2013.
• PMID:

• Caudal vena caval thrombosis following treatment of deep digital sepsis.
• Simpson KM, Streeter RN, Cramer S, Lamm CG, Love BC.
• Can Vet J. 2012 Feb;53(2):182-6.
• PMID: 22851781

• Pathology in practice. Brain neoplasm.
• Cramer SD, Campbell GA, Gray CW, Lamm CG.
• J Am Vet Med Assoc. 2012 Jan 1;240(1):47-9. doi: 10.2460/javma.240.1.47. No abstract available.
• PMID: 22171754

• Pseudorabies virus infection in Oklahoma hunting dogs.
• Cramer SD, Campbell GA, Njaa BL, Morgan SE, Smith SK 2nd, McLin WR 4th, Brodersen BW, Wise AG, Scherba G, Langohr IM, Maes RK
• J Vet Diagn Invest. 2011 Sep;23(5):915-23. doi: 10.1177/1040638711416628. Erratum in: J Vet Diagn Invest. 2012 Jan;24(1):246
• PMID: 21908347

• Clinical Snapshot—Colitis in a Paint Gelding.
• Cramer SD, Love B, Ritchey JW, Banse H.
• Compendium Equine, 2011 Dec; 33(12): online access
• PMID:

• Pathology in practice. Liposarcoma.
• Cramer SD, Porter KL, Rochat MC, Lamm CG.
• J Am Vet Med Assoc. 2011 Sep 15;239(6):757-9. doi: 10.2460/javma.239.6.757. No abstract available.
• PMID: 21916756

• Pathology in practice. Thymic lymphoma with vertebral bone marrow involvement, spinal cord compression, and Wallerian degeneration.
• Cramer SD, Njaa BL, Genova SG, Gilliam JN.
• J Am Vet Med Assoc. 2011 Jun 15;238(12):1565-7. doi: 10.2460/javma.238.12.1565. No abstract available.
• PMID: 21671810

• Sellar xanthogranuloma in a dog.
• Cramer SD, Miller AD, Medici EL, Brunker JD, Ritchey JW.
• J Vet Diagn Invest. 2011 Mar;23(2):387-90.
• PMID: 21398471

• Pathology in practice. Squamous cell carcinoma of the penis with multifocal metastasis to the regional lymph nodes, lungs, and heart.
• Cramer SD, Breshears MA, Qualls HJ.
• J Am Vet Med Assoc. 2011 Mar 1;238(5):581-3. doi: 10.2460/javma.238.5.581. No abstract available.
• PMID: 21355798

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Schantel (Hayes) Bouknight, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2010

• Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11.
• Gregory-Bryson E, Bartlett E, Kiupel M, Hayes S, Yuzbasiyan-Gurkan V.
• BMC Cancer. 2010 Oct 15;10:559.
• PMID: 20950418

• Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1.
• Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, Hugendubler L, Fejes-Toth G, Naray-Fejes-Toth A, Mueller E.
• Mol Endocrinol. 2010 Feb;24(2):370-80. Epub 2009 Dec 4.
• PMID: 19965929

• B-cell lymphoma in the peripheral nerves of a cat.
• Higgins MA, Rossmeisl JH Jr, Saunders GK, Hayes S, Kiupel M.
• Vet Pathol. 2008 Jan;45(1):54-7.
• PMID: 18192576

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Stacey Piotrowski, D.V.M.

• Diplomate, ACVP

• Development and Characterization of a Rabbit Model of Compromised Maxillofacial Wound Healing.
• Stacey L. Piotrowski, Lindsay Wilson, Neeraja Dharmaraj, Amani Hamze, Ashley Clark, Ramesh Tailor, Lori R. Hill, Stephen Lai, F. Kurtis Kasper, Simon Young.
• Tissue Engineering Part C. 2019, 25:160-167.
• PMID: 30747042

• Anti-tumor Immunity Induced by Ectopic Expression of Viral Antigens is Transient and Limited by Immune Escape.
• Neeraja Dharmaraj, Stacey L. Piotrowski, Chen Huang, Jared M. Newton, Leonard S. Golfman, Aurelie Hanoteau, Sandeep T. Koshy, Aileen W. Li, Merlyn X. Pulikkathara, Bing Zhang, Jared K. Burks, David J. Mooney, Yu L. Lei, Andrew G. Sikora, Simon Young.
• OncoImmunology. 2019, 8:1-13.
• PMID: 30906661

• Effect of Radiation on DCE-MRI Pharmacokinetic Parameters in a Rabbit Model of Compromised Maxillofacial Wound Healing: A Pilot Study.
• Piotrowski, S.L, Wilson, L., Maldonado, K.L, Tailor, R., Hill, L.R, Bankson, J.A., Lai, S., Kasper, F. K., Young, S.
• Journal of Oral and Maxillofacial Surgery 78(6): 1034.e1-1034.e10. 2020.
• PMID: 32147226

• Feline pituitary neuroendocrine tumors: correlation of histologic and immunohistochemical characteristics with clinical findings and case outcome.
• Miller, M.A., Piotrowski, S.L., Donovan, T.A., Scott-Moncrief, J.C., Owen, T.J., McCue, J.P., DuSold, D.M., Ramos-Vara, J.A., Weng, H., Chen, A.V., Martin, L.G., Bruyette, D.S.
• Veterinary Pathology 58(2): 266-275. 2021
• PMID: 33280571

• Pathology in Practice: Legg-Calvé-Perthes Disease in a Juvenile Rhesus Macaque.
• Piotrowski, S.L., Gagea, M., Huang, S.Y., Shetty, G., Hill, L.R.
• Journal of the American Veterinary Medical Association 258(2): 161-164. 2021
• PMID: 33405981

• STINGel: Controlled Release of a Cyclic Dinucleotide for Enhanced Cancer Immunotherapy.
• Leach, D.G., Dharmaraj, N., Piotrowski, S.L., Lopez-Silva, T.L., Lei, Y.L., Sikora, A.G., Young, S., Hartgerink, J.D.
• Biomaterials 163:67-75. 2018
• PMID: 29454236

• Histopathologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice: A Review.
• Hsu, C.C., Piotrowski, S.L., Meeker, S.M., Smith, K.D., Maggio-Price, L., Treuting, P.M.
• Veterinary Pathology 53(4): 754-763. 2016.
• PMID: 26792844

• Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury
• Robinson, M.A., Jaber, S. M., Piotrowski, S. L., Gomez, T.H.
• Pre-Clinical and Clinical Methods in Brain Trauma Research. Neuromethods Series, Springer, New York (2018).
• PMID:

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Tanasa S. Osborne, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2011

• A review of the association between osteosarcoma metastasis and protein translation.
• Osborne TS, Khanna C.
• J Comp Pathol. 2012 Feb-Apr;146(2-3):132-42. doi: 10.1016/j.jcpa.2011.12.007. Epub 2012 Jan 31. Review.
• PMID: 22297074

• Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray.
• Osborne TS, Ren L, Healey JH, Shapiro LQ, Chou AJ, Gorlick RG, Hewitt SM, Khanna C.
• J Pediatr Hematol Oncol. 2011 Oct;33(7):524-8. doi: 10.1097/MPH.0b013e318223d0c1.
• PMID: 21941146

• Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.
• Hong SH, Osborne T, Ren L, Briggs J, Mazcko C, Burkett SS, Khanna C.
• Vet Comp Oncol. 2011 Sep;9(3):207-18. doi: 10.1111/j.1476-5829.2010.00249.x. Epub 2010 Dec 14.
• PMID: 21848623

• Modeling metastasis biology and therapy in real time in the mouse lung.
• Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir el H, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
• J Clin Invest. 2010 Aug 2;120(8):2979-88. doi: 10.1172/JCI40252. Epub 2010 Jul 19. Erratum in: J Clin Invest. 2010 Oct 1;120(10):3735. Dakir, el-H [corrected to Dakir, El Habib].
• PMID: J Clin Invest.

• Science & Alumni CBSTP Alumni Science & Publications Home• Science & Alumni • Science & Publications Science & Publications Graduate Publications Laura Baseler (2015 Graduate) Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With
• Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, Vail DM, Nuckolls K, Osborne T, Yalkowsy S, Gustafson D, Yu Y, Cao L, Khanna C.
• PLoS One. 2010 Jun 8;5(6):e11013.
• PMID: 20543980

• Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.
• Abdeen A, Chou AJ, Healey JH, Khanna C, Osborne TS, Hewitt SM, Kim M, Wang D, Moody K, Gorlick R.
• Cancer. 2009 Nov 15;115(22):5243-50.
• PMID: 19670450

• The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.
• Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C
• Oncogene. 2009 Feb 12;28(6):792-802. Epub 2008 Dec 8.
• PMID: 19060919

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Tiffany (Reed) Lyle, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2016

• Alterations in Pericyte Subpopulations are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer.
• Lyle LT, Lockman PR, Adkins CE, Mohammad AS, Sechrest E, Hua E, Palmieri D, Liewehr DJ, Steinberg SM, Kloc W, Izycka-Swieszewska E, Duchnowska R, Nayyar N, Brastianos PK, Steeg PS, Gril B.
• Clin Cancer Res. 2016 May 31. pii: clincanres.1836.2015. [Epub ahead of print]
• PMID: 27245829

• Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
• Hernandez L, Kim MK, Lyle LT, Bunch KP, House CD, Ning F, Noonan AM, Annunziata CM. Gynecol Oncol. 2016
• Aug;142(2):332-40. doi: 10.1016/j.ygyno.2016.05.028. Epub 2016 May 28.
• PMID: 27235858

• DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.
• Woditschka S, Evans L, Duchnowska R, Reed LT, Palmieri D, Qian Y, Badve S, Sledge G Jr, Gril B, Aladjem MI, Fu H, Flores NM, Gökmen-Polar Y, Biernat W, Szutowicz-Zieli?ska E, Mandat T, Trojanowski T, Och W, Czartoryska-Arlukowicz B, Jassem J, Mitchell JB, Steeg PS.
• J Natl Cancer Inst. 2014 Jun 19;106(7). pii: dju145. doi: 10.1093/jnci/dju145. Print 2014 Jul.
• PMID: 24948741

• Breast cancer metastasis: issues for the personalization of its prevention and treatment.
• Marino N, Woditschka S, Reed LT, Nakayama J, Mayer M, Wetzel M, Steeg PS.
• Am J Pathol. 2013 Oct;183(4):1084-95. doi: 10.1016/j.ajpath.2013.06.012. Epub 2013 Jul 26.
• PMID: 23895915

• “Central Nervous System Metastasis, The Biological Basis and Clinical Considerations.”
• Woditschka S, Gril B, Evans L, Reed LT, Steeg P.
• Cancer Metastasis –Biology and Treatment: The Molecular Biology of Brain Metastases. Ed. Palmieri D. Dordrecht: Springer, 2012. 18 (15-41).
• PMID:

• Cutaneous Metastasis of Transitional Cell Carcinoma in 12 Dogs.
• Reed LT, Knapp DW, Miller MA.
• Vet Pathol. 2012 Nov 6 [Epub ahead of print]
• PMID: 23136183

• Diagnostic exercise: cerebral mass in a puppy with respiratory distress and progressive neurologic signs.
• Reed LT, Miller MA, Visvesvara GS, Gardiner CH, Logan MA, Packer RA.
• Vet Pathol. 2010 Nov;47(6):1116-9. Epub 2010 Jul 15.
• PMID: 20634413

• Pathology in practice. Granulomatous pneumonia, prostatitis and uveitis with intralesional yeasts consistent with Blastomyces.
• Reed LT, Balog KA, Boes KM, Messick JB, Miller MA.
• J Am Vet Med Assoc. 2010 Feb 15;236(4):411-3. No abstract available.
• PMID: 20151862

• Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
• Wei BR, Edwards JB, Hoover SB, Tillman HS, Reed LT, Sills RC, Simpson RM.
• Toxicol Pathol. 2008;36(7):972-80. Epub 2008 Oct 31.
• PMID: 18978308

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Tyler Peat, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2020

• Fatty Acid Patterns Detected By Ambient Ionization Mass Spectrometry in Canine Invasive Urothelial Carcinoma From Dogs of Different Breeds.
• D'Hue CA, Dhawan D, Peat T, Ramos-Vara J, Jarmusch A, Knapp DW, Cooks RG.
• Bladder Cancer. 2018 Jul 30;4(3):283-291. doi: 10.3233/BLC-170125.
• PMID: 30112439

• Pathology in Practice: Mulberry heart disease in a two-month-old crossbred gilt.
• Peat TJ, Miller MA.
• J Am Vet Med Assoc. 2018 Sep 15;253(6):719-721. doi: 10.2460/javma.253.6.719.
• PMID: 30179087

• Pax8, Napsin A, and CD10 as Immunohistochemical Markers of Canine Renal Cell Carcinoma.
• Peat TJ, Edmondson EF, Miller MA, DuSold DM, Ramos-Vara JA.
• Vet Pathol. 2017 Jul;54(4):588-594. doi: 10.1177/0300985817698211. Epub 2017 Mar 27
• PMID: 28346124

• Characteristic lipid profiles of canine non-Hodgkin's lymphoma from surgical biopsy tissue sections and fine needle aspirate smears by desorption electrospray ionization--mass spectrometry.
• Jarmusch AK, Kerian KS, Pirro V, Peat T, Thompson CA, Ramos-Vara JA, Childress MO, Cooks RG.
• Analyst. 2015 Sep 21;140(18):6321-9. doi: 10.1039/c5an00825e.
• PMID: 26236993

• The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription.
• Malik N, Yan H, Moshkovich N, Palangat M, Yang H, Sanchez V, Cai Z, Peat TJ, Jiang S, Liu C, Lee M, Mock BA, Yuspa SH, Larson D, Wakefield LM, Huang J.
• Nat Commun. 2019 May 6;10(1):2071. doi: 10.1038/s41467-019-10102-6.
• PMID: 31061501

• Attenuation of immune mediated bone marrow damage in conventionally-housed mice.
• Li J, Dubois W, Thovariai V, Wu Z, Feng X, Peat TJ, Zhang S, Sen S, Trinchieri G, Chen J, Mock BA, Young NS. Attenuation of immune mediated bone marrow damage in conventionally-housed mice.
• Molecular Carcinogenesis. 2020 Feb;59(2):237-245.
• PMID: 31898340

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Yava Jones-Hall, D.V.M., Ph.D.

• Diplomate, ACVP
• Program Graduate 2010

• MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
• Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
• J Exp Med. 2010 Aug 2;207(8):1625-36. Epub 2010 Jul 12.
• PMID: 20624890

• Articular gout and suspected pseudogout in a Basilisk lizard (Basilicus plumifrons).
• Jones YL, Fitzgerald SD.
• J Zoo Wildl Med. 2009 Sep;40(3):576-8.
• PMID: 19746877

• Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography.
• Young MR, Ileva LV, Bernardo M, Riffle LA, Jones YL, Kim YS, Colburn NH, Choyke PL.
• Neoplasia. 2009 Mar;11(3):237-46, 1p following 246.
• PMID: 19242605

• Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.
• Zarfoss MK, Klauss G, Newkirk K, Kiupel M, Jones Y, Colitz CM, Dubielzig RR.
• Vet Pathol. 2007 May;44(3):276-84.
• PMID: 17491068

• Toxoplasmosis in a free-ranging mink.
• Jones YL, Fitzgerald SD, Sikarske JG, Murphy A, Grosjean N, Kiupel M.
• J Wildl Dis. 2006 Oct;42(4):865-9.
• PMID: 17255457

• Peliod hepatocellular carcinoma in a domesticated ferret (Mustela putorius furo).
• Jones Y, Wise A, Maes R, Kiupel M.
• J Vet Diagn Invest. 2006 Mar;18(2):228-31.
• PMID: 16617711

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Adrianne Glaser, D.V.M.

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Chaunte Lewis, D.V.M.

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DaZané Cole, D.V.M.

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Helena Vogel, D.V.M.

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Hilary Ann Lakin, D.V.M.

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Jessica Rizor, D.V.M.

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Katelin Davis, D.V.M.

• Diagnosis of Collagen Type III Glomerulopathy Using Picrosirius Red and PASH/Masson’s Trichrome Stain
• Katelin L. Davis, Anne L. Burnum, Jessica A. Beck, Shannon G. M. Kirejczyk, Margaret A. Miller, Mario F. Sola, and Cathy A. Brown
• PMID: 32880237

• Pathology Associated With Streptococcus spp. Infection in Baboons (Papio spp.)
• Katelin L. Davis, Olga Gonzalez, Shyamesh Kumar, and Edward J. Dick Jr.
• PMID: 32744146

• Malakoplakia in the Urinary Bladder of 4 Puppies
• Katelin L. Davis, Liang Cheng, Jose Ramos-Vara, Melissa D. Sanchez, Rebecca P. Wilkes, and Mario F. Sola
• PMID: 33888013

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Kerry Goldin, D.V.M.

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Kyleigh Tyler, D.V.M.

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Patrick Huang, D.V.M.

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Steven Hsu, D.V.M.

• Diplomate, ACVP

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Zachary Millman, D.V.M.

• Diplomate, ACVP

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