Dr. Osborne was a graduate scholar in the NCI molecular pathology GPP in partnership with the University of Illinois, Urbana-Champaign and the National Cancer Institute, from 2006 to 2010.
Dr. Tanasa Osborne received her Doctorate of Veterinary Medicine (DVM) from Tuskegee University College of Veterinary Medicine in 2002. That same year, Dr. Osborne entered a combined residency/PhD training program in anatomic pathology with an emphasis on toxicologic pathology in the Department of Pathobiology at the University of Illinois at Urbana-Champaign. Upon completion of her residency in 2006 Dr. Osborne began graduate training in comparative pathology through the GPP at the NCI, Bethesda, MD. Her PhD dissertation research in metastasis biology was carried out in the Tumor and Metastasis Biology Section, headed by Chand Khanna, DVM, PhD in the Pediatric Oncology Branch. Her model system included using a transplantable syngeneic mouse model characterized by orthotopic growth of osteosarcoma in BALB/c mice at appendicular sites with spontaneous metastasis to the lung. She used this model to study the role of eukaryotic initiation factor 4E (eIF4E) in the various steps of the metastatic cascade in osteosarcoma. The title of her dissertation was “The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis”. Members of her graduate guidance committee included: Wanda Haschek-Hock, BVSc, PhD, Diplomate, American College of Veterinary Pathologists and American Board of Toxicologists (Chair), Chand Khanna, DVM, PhD, Diplomate, American College of Veterinary Internal Medicine, Matthew A. Wallig, DVM, PhD, Diplomate, American College of Veterinary Pathologists, Lois L. Hoyer, PhD, and Timothy M. Fan, DVM, PhD, Diplomate, American College of Veterinary Internal Medicine. Dr. Osborne joined the National Toxicology Program (NTP) Pathology Group at the National Institutes of Health Sciences (NIEHS) in 2012 as a Toxicologic Pathology Research Fellow. She participated in the design, evaluation, and interpretation of toxicity and carcinogenicity studies conducted at NTP contracted laboratories. She gained invaluable experience in rodent toxicology studies and was able to contribute to the establishment of standards, nomenclature, and diagnostic criteria for rodent pathology. Her fellowship allowed continued education toward enhancing molecular pathology techniques and specialized training in hepatobiliary toxicology. She is now employed as a Project Pathologist at Novartis Institutes for Biomedical Research.
