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Graduate Publications


Laura Baseler (2015 Graduate)

Syrian Hamsters (Mesocricetus auratus) Oronasally Inoculated With a Nipah Virus Isolate From Bangladesh or Malaysia Develop Similar Respiratory Tract Lesions.

Baseler L, de Wit E, Scott DP, Munster VJ, Feldmann H.

Vet Pathol. 2015 Jan;52(1):38-45. doi: 10.1177/0300985814556189. Epub 2014 Oct 28.

PMID: 25352203

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques.

Falzarano D, de Wit E, Rasmussen AL, Feldmann F, Okumura A, Scott DP, Brining D, Bushmaker T, Martellaro C, Baseler L, Benecke AG, Katze MG, Munster VJ, Feldmann H.

Nat Med. 2013 Oct;19(10):1313-7. doi: 10.1038/nm.3362. Epub 2013 Sep 8.

PMID: 24013700

The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters.

de Wit E, Prescott J, Baseler L, Bushmaker T, Thomas T, Lackemeyer MG, Martellaro C, Milne-Price S, Haddock E, Haagmans BL, Feldmann H, Munster VJ.

PLoS One. 2013 Jul 2;8(7):e69127. doi: 10.1371/journal.pone.0069127. Print 2013.

PMID: 23844250

Arsenic toxicosis in cattle: meta-analysis of 156 cases.

Bertin FR, Baseler LJ, Wilson CR, Kritchevsky JE, Taylor SD.

J Vet Intern Med. 2013 Jul-Aug;27(4):977-81. doi: 10.1111/jvim.12124. Epub 2013 Jun 12. Review.

PMID: 23758199


David Caudell (2008 Graduate)

Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques.

DeBo RJ, Register TC, Caudell DL, Sempowski GD, Dugan G, Gray S, Owzar K, Jiang C, Bourland JD, Chao NJ, Cline JM.

Int J Radiat Biol. 2015 Jun;91(6):510-8. doi: 10.3109/09553002.2015.1028597. Epub 2015 Apr 22.

PMID: 25786585

Assessment of Multiplate platelet aggregometry using citrate, heparin or hirudin in Rhesus macaques.

Dugan G, O'Donnell L, Hanbury DB, Cline JM, Caudell DL.

Platelets. 2014 Dec 30:1-6. [Epub ahead of print]

PMID: 25549285

DMP1β, a splice isoform of the tumour suppressor DMP1 locus, induces proliferation and progression of breast cancer.

Maglic D, Stovall DB, Cline M, Fry EA, Mallakin A, Taneja P, Caudell DL, Willingham MC, Sui G, Inoue K.

J Pathol. 2014 Dec 24. doi: 10.1002/path.4504. [Epub ahead of print]

PMID: 25537728

Mechanisms of human erythrocytic bioactivation of nitrite.

Liu C, Wajih N, Liu X, Basu S, Janes J, Marvel M, Keggi C, Helms CC, Lee AN, Belanger AM, Diz DI, Laurienti PJ, Caudell DL, Wang J, Gladwin MT, Kim-Shapiro DB.

J Biol Chem. 2015 Jan 9;290(2):1281-94. doi: 10.1074/jbc.M114.609222. Epub 2014 Dec 3.

PMID: 25471374

The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.

Cook GJ, Caudell DL, Elford HL, Pardee TS.

PLoS One. 2014 Nov 17;9(11):e112619. doi: 10.1371/journal.pone.0112619. eCollection 2014.

PMID: 25402485

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells.

Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH.

Oncotarget. 2014 Jun 30;5(12):4170-9.

PMID: 24961587

Class I and II histone deacetylase inhibition by ITF2357 reduces SLE pathogenesis in vivo.

Regna NL, Chafin CB, Hammond SE, Puthiyaveetil AG, Caudell DL, Reilly CM.

Clin Immunol. 2014 Mar;151(1):29-42. doi: 10.1016/j.clim.2014.01.002. Epub 2014 Jan 15.

PMID: 24503172

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells.

Pardee TS, Stadelman K, Jennings-Gee J, Caudell DL, Gmeiner WH.

Oncotarget. 2014 May 1. [Epub ahead of print]

PMID: 24961587

MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFκB activation in vitro.

Chafin CB, Regna NL, Caudell DL, Reilly CM.

Cell Mol Immunol. 2014 Jan;11(1):79-83. doi: 10.1038/cmi.2013.51. Epub 2013 Nov 18.

PMID: 24240124

MicroRNA-let-7a expression is increased in the mesangial cells of NZB/W mice and increases IL-6 production in vitro.

Chafin CB, Regna NL, Dai R, Caudell DL, Reilly CM.

Autoimmunity. 2013 Sep;46(6):351-62. doi: 10.3109/08916934.2013.773976.

PMID: 24001203

Diverging in vitro antibody isotype switching preference in B-lymphocytes from C57BL/6 and FVB mice.

Puthiyaveetil AG, Okyere B, Reilly CM, Caudell D.

In Vivo. 2013 Jan-Feb;27(1):29-39.

PMID: 23239849

Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome.

Puthiyaveetil AG, Reilly CM, Pardee TS, Caudell DL.

Leuk Res. 2013 Jan;37(1):112-6. doi: 10.1016/j.leukres.2012.10.012. Epub 2012 Nov 4.

PMID: 23131583

Non homologous end joining-mediated DNA break repair is impaired in B lymphocytes of aging mice.

Puthiyaveetil AG, Caudell DL.

Mol Immunol. 2013 Jan;53(1-2):79-87. doi: 10.1016/j.molimm.2012.07.001. Epub 2012 Aug 9.

PMID: 22878140

Gene expression profiling and candidate gene resequencing identifies pathways and mutations important for malignant transformation caused by leukemogenic fusion genes.

Novak RL, Harper DP, Caudell D, Slape C, Beachy SH, Aplan PD.

Exp Hematol. 2012 Dec;40(12):1016-27. doi: 10.1016/j.exphem.2012.08.001. Epub 2012 Aug 8.

PMID: 22885519

A NUP98-HOXD13 leukemic fusion gene leads to impaired class switch recombination and antibody production.

Puthiyaveetil AG, Heid B, Reilly CM, HogenEsch H, Caudell DL.

Exp Hematol. 2012 Aug;40(8):622-33. doi: 10.1016/j.exphem.2012.05.002. Epub 2012 May 18.

PMID: 22613470

Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus.

Shimp SK 3rd, Chafin CB, Regna NL, Hammond SE, Read MA, Caudell DL, Rylander M, Reilly CM.

Cell Mol Immunol. 2012 May;9(3):255-66. doi: 10.1038/cmi.2012.5. Epub 2012 Apr 30.

PMID: 22543833

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.

Pardee TS, Gomes E, Jennings-Gee J, Caudell D, Gmeiner WH.

Blood. 2012 Apr 12;119(15):3561-70. doi: 10.1182/blood-2011-06-362442. Epub 2012 Feb 23.

PMID: 22362039

Identification of a Common Lupus Disease-Associated microRNA Expression Pattern in Three Different Murine Models of Lupus.
Dai R, Zhang Y, Khan D, Heid B, Caudell D, Crasta O, Ahmed SA.
PLoS One. 2010 Dec 10;5(12):e14302.
PMID: 21170274

Phalaris arundinacea (reed canarygrass) grass staggers in beef cattle.
Binder EM, Blodgett DJ, Currin JF, Caudell D, Cherney JH, LeRoith T.
J Vet Diagn Invest. 2010 Sep;22(5):802-5.
PMID: 20807948

Efficacy of an orange oil emulsion as an anthelmintic against Haemonchus contortus in gerbils (Meriones unguiculatus) and in sheep.
Squires JM, Foster JG, Lindsay DS, Caudell DL, Zajac AM.
Vet Parasitol. 2010 Aug 27;172(1-2):95-9. Epub 2010 Apr 18.
PMID: 20452126

Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice.
Caudell D, Harper DP, Novak RL, Pierce RM, Slape C, Wolff L, Aplan PD.
Blood. 2010 Feb 11;115(6):1194-203. Epub 2009 Dec 9.
PMID: 20007546

The role of CALM-AF10 gene fusion in acute leukemia.
Caudell D, Aplan PD.
Leukemia. 2008 Apr;22(4):678-85. Epub 2007 Dec 20. Review.
PMID: 18094714

Quantification of HTLV-I proviral load in experimentally infected rabbits.
Zhao TM, Hague B, Caudell DL, Simpson RM, Kindt TJ.
Retrovirology. 2005 May 23;2:34.
PMID: 15910683

Ocular penetration of oral doxycycline in the horse.
Gilmour MA, Clarke CR, Macallister CG, Dedeo JM, Caudell DL, Morton RJ, Pugh M.
Vet Ophthalmol. 2005 Sep-Oct;8(5):331-5.
PMID: 16178844

Diagnosis of infectious canine hepatitis virus (CAV-1) infection in puppies with encephalopathy.
Caudell D, Confer AW, Fulton RW, Berry A, Saliki JT, Fent GM, Ritchey JW.
J Vet Diagn Invest. 2005 Jan;17(1):58-61. Erratum in: J Vet Diagn Invest. 2005 Sep;17(5):502.
PMID: 15690952

Paresis secondary to an extradural hematoma in a Sumatran tiger (Panthera tigris sumatrae).
Ketz-Riley CJ, Galloway DS, Hoover JP, Rochat MC, Bahr RJ, Ritchey JW, Caudell DL.
J Zoo Wildl Med. 2004 Jun;35(2):208-15.
PMID: 15305517


Sarah Cramer

Therapeutic targeting of IL-7Rα signaling pathways in ALL treatment.

Cramer SD, Aplan PD, Durum SK.

Blood. 2016 Jul 28;128(4):473-8. doi: 10.1182/blood-2016-03-679209. Epub 2016 Jun 6. Review.

PMID: 27268088

Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment.

Iida N, Dzutsev A, Stewart CA, Smith L, Bouladoux N, Weingarten RA, Molina DA, Salcedo R, Back T, Cramer S, Dai RM, Kiu H, Cardone M, Naik S, Patri AK, Wang E, Marincola FM, Frank KM, Belkaid Y, Trinchieri G, Goldszmid RS.

Science. 2013 Nov 22;342(6161):967-70. doi: 10.1126/science.1240527.

PMID: 24264989

SD Cramer. Chapter 25: Pseudorabies. In JE Sykes, editor, Canine and Feline Infectious Diseases.

Elsevier, St. Louis, MO, 2013.

Caudal vena caval thrombosis following treatment of deep digital sepsis.

Simpson KM, Streeter RN, Cramer S, Lamm CG, Love BC.

Can Vet J. 2012 Feb;53(2):182-6.

PMID: 22851781

Pathology in practice. Brain neoplasm.

Cramer SD, Campbell GA, Gray CW, Lamm CG.

J Am Vet Med Assoc. 2012 Jan 1;240(1):47-9. doi: 10.2460/javma.240.1.47. No abstract available.

PMID: 22171754

Pseudorabies virus infection in Oklahoma hunting dogs.

Cramer SD, Campbell GA, Njaa BL, Morgan SE, Smith SK 2nd, McLin WR 4th, Brodersen BW, Wise AG, Scherba G, Langohr IM, Maes RK. 

J Vet Diagn Invest. 2011 Sep;23(5):915-23. doi: 10.1177/1040638711416628. Erratum in: J Vet Diagn Invest. 2012 Jan;24(1):246.

PMID: 21908347

Clinical Snapshot—Colitis in a Paint Gelding.

Cramer SD, Love B, Ritchey JW, Banse H.

Compendium Equine, 2011 Dec; 33(12): online access

Pathology in practice. Liposarcoma.

Cramer SD, Porter KL, Rochat MC, Lamm CG.

J Am Vet Med Assoc. 2011 Sep 15;239(6):757-9. doi: 10.2460/javma.239.6.757. No abstract available.

PMID: 21916756

Pathology in practice. Thymic lymphoma with vertebral bone marrow involvement, spinal cord compression, and Wallerian degeneration.

Cramer SD, Njaa BL, Genova SG, Gilliam JN.

J Am Vet Med Assoc. 2011 Jun 15;238(12):1565-7. doi: 10.2460/javma.238.12.1565. No abstract available.

PMID: 21671810

Sellar xanthogranuloma in a dog.

Cramer SD, Miller AD, Medici EL, Brunker JD, Ritchey JW.

J Vet Diagn Invest. 2011 Mar;23(2):387-90.

PMID: 21398471

Pathology in practice. Squamous cell carcinoma of the penis with multifocal metastasis to the regional lymph nodes, lungs, and heart.

Cramer SD, Breshears MA, Qualls HJ.

J Am Vet Med Assoc. 2011 Mar 1;238(5):581-3. doi: 10.2460/javma.238.5.581.  No abstract available.

PMID: 21355798


Anne Sally Davis (2014 Graduate)

The use of nonhuman primates in research on seasonal, pandemic and avian influenza, 1893-2014.

Davis AS, Taubenberger JK, Bray M.

Antiviral Res. 2015 May;117:75-98. doi: 10.1016/j.antiviral.2015.02.011. Epub 2015 Mar 5. Review.

PMID: 25746173

Validation of normal human bronchial epithelial cells as a model for influenza A infections in human distal trachea.

Davis AS, Chertow DS, Moyer JE, Suzich J, Sandouk A, Dorward DW, Logun C, Shelhamer JH, Taubenberger JK.

J Histochem Cytochem. 2015 May;63(5):312-28. doi: 10.1369/0022155415570968. Epub 2015 Jan 20.

PMID: 25604814

Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin.

Qi L, Pujanauski LM, Davis AS, Schwartzman LM, Chertow DS, Baxter D, Scherler K, Hartshorn KL, Slemons RD, Walters KA, Kash JC, Taubenberger JK.

MBio. 2014 Nov 18;5(6):e02116. doi: 10.1128/mBio.02116-14.

PMID: 25406382

Pneumocystis Encodes a Functional Endo-β-1,3-glucanase That is Expressed Exclusively in Cysts.

Kutty G, Davis AS, Ma L, Taubenberger JK, Kovacs JA.

J Infect Dis. 2014 Sep 17. pii: jiu517. [Epub ahead of print]

PMID: 25231017

Characterizing and Diminishing Autofluorescence in Formalin-fixed Paraffin-embedded Human Respiratory Tissue.

Davis AS, Richter A, Becker S, Moyer JE, Sandouk A, Skinner J, Taubenberger JK.

J Histochem Cytochem. 2014 Apr 30. [Epub ahead of print]

PMID: 24722432

Treatment with the reactive oxygen species scavenger EUK-207 reduces lung damage and increases survival during 1918 influenza virus infection in mice.  

Kash JC, Xiao Y, Davis AS, Walters KA, Chertow DS, Easterbrook JD, Dunfee RL, Sandouk A, Jagger BW, Schwartzman LM, Kuestner RE, Wehr NB, Huffman K, Rosenthal RA, Ozinsky A, Levine RL, Doctrow SR, Taubenberger JK. 

Free Radic Biol Med. 2013 Oct 17;67C:235-247. doi: 10.1016/ j.freeradbiomed.2013.10.014. [Epub ahead]   

PMID: 24140866

Changes in MicroRNA and mRNA expression with Differentiation of Human Bronchial Epithelial Cells.  

Martinez-Anton A, Sokolowska M, Kern S, Davis AS, Alsaaty S, Taubenberger JK, Sun J, Cai R, Danner RL, Eberlein M, Logun C, ShelhamerJH. 

Am J Respir Cell Mol Biol. 2013 Apr 13. 

PMID: 23590309

 Analysis by single-gene reassortment demonstrates that the 1918 influenza virus is functionally compatible with a low-pathogenicity avian influenza virus in mice.

Qi L, Davis AS, Jagger BW, Schwartzman LM, Dunham EJ, Kash JC, Taubenberger JK.

J Virol. 2012 Sep;86(17):9211-20. doi: 10.1128/JVI.00887-12. Epub 2012 Jun 20.

PMID: 22718825

In vivo evaluation of pathogenicity and transmissibility of influenza A(H1N1)pdm09 hemagglutinin receptor binding domain 222 intrahost variants isolated from a single immunocompromised patient.

Memoli MJ, Bristol T, Proudfoot KE, Davis AS, Dunham EJ, Taubenberger JK.

Virology. 2012 Jun 20;428(1):21-9. doi: 10.1016/j.virol.2012.02.018.

PMID: 22575875

Lethal synergism of 2009 pandemic H1N1 influenza virus and Streptococcus pneumoniae coinfection is associated with loss of murine lung repair responses.

Kash JC, Walters KA, Davis AS, Sandouk A, Schwartzman LM, Jagger BW, Chertow DS, Li Q, Kuestner RE, Ozinsky A, Taubenberger JK.

MBio. 2011 Sep 20;2(5). pii: e00172-11. doi: 10.1128/mBio.00172-11. Print 2011.

PMID: 21933918

Global rinderpest eradication: lessons learned and why humans should celebrate too.

Morens DM, Holmes EC, Davis AS, Taubenberger JK. 

J Infect Dis. 2011 Aug 15;204(4):502-5. doi: 10.1093/infdis/jir327.

Epub 2011 Jun 7. No abstract available.

PMID: 21653230

Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain fitness and transmissibility in ferrets.

Memoli MJ, Davis AS, Proudfoot K, Chertow DS, Hrabal RJ, Bristol T, Taubenberger JK.

J Infect Dis. 2011 Feb 1;203(3):348-57. doi: 10.1093/infdis/jiq067. Epub 2010 Dec 20.

PMID: 21208927

Metastatic growth from dormant cells induced by a col-I-enriched fibrotic environment.
Barkan D, El Touny LH, Michalowski AM, Smith JA, Chu I, Davis AS, Webster JD, Hoover S, Simpson RM, Gauldie J, Green JE. 

Cancer Res. 2010 Jul 15;70(14):5706-16. Epub 2010 Jun 22.
PMID: 20570886

Gross and histologic evaluation of 5 suture materials in the skin and subcutaneous tissue of the California sea hare (Aplysia californica).
Anderson ET, Davis AS, Law JM, Lewbart GA, Christian LS, Harms CA.
J Am Assoc Lab Anim Sci. 2010 Jan;49(1):64-8.
PMID: 20122319

Joy Gary (2015 Graduate)

Enteric Colonization by Staphylococcus delphini in Four Ferret Kits with Diarrhoea.                                            

Gary JM, Langohr IM, Lim A, Bolin S, Bolin C, Moore I, Kiupel M.

J Comp Pathol. 2014 Nov;151(4):314-7. doi: 10.1016/j.jcpa.2014.08.004. Epub 2014 Sep 22.

PMID: 25246181

B cell-specific deficiencies in mTOR limit humoral immune responses.

Zhang S, Pruitt M, Tran D, Du Bois W, Zhang K, Patel R, Hoover S, Simpson RM, Simmons J, Gary J, Snapper CM, Casellas R, Mock BA.

J Immunol. 2013 Aug 15;191(4):1692-703. doi: 10.4049/jimmunol.1201767. Epub 2013 Jul 15.

PMID: 23858034

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.
Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.
PMID: 24128326

T cell rich, B cell lymphoma in the small colon of a yearling horse.

Smith KM, Clark CK, Kiupel M, Gary J.

Equine Veterinary Education. 2012 March 28. Advance online publication.

Medium-grade astrocytoma in a cougar (Puma concolor).  

Kondo H, Leone AM, Erlacher-Reid C, Gary J, Kiupel M, Farina LL, Abbott JR. 

J Zoo Wildl Med. 2012 Dec;43(4):956-60.   

PMID: 23272372

Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland.        
Wood CE, Hester JM, Appt SE, Geisinger KR, Cline JM.
Lab Invest. 2008 Sep;88(9):938-48. doi: 10.1038/labinvest.2008.64. Epub 2008 Jul 7. 
PMID: 18607345                                                                                                                                          

Effects of relocation on movements and home ranges of eastern box turtles (Terrapene carolina). 
Hester JM, Price SJ, and Dorcas ME.   
Journal of Wildlife Management. 2008; 72 (3): 772-777.

The Davidson College Box Turtle Mark-Recapture Program: Urban Herpetological Research Made Possible by Citizen Scientists.    
Hester JM, Budischak SA, and Dorcas ME. 
In R. E. Jung and J. C. Mitchell (eds.), Urban Herpetology. Herpetological Conservation Vol. 3, Society for the Study of Amphibians and Reptiles. 2008;  Salt Lake City, UT.

Mammary gland development in early pubertal female macaques.                                                                      Wood CE, Hester JM, and Cline JM.                                                                                                             Toxicol Pathol. 2007 Oct;35(6):795-805.                                                                                                          PMID: 17943653

Natural history of box turtles, Terrapene carolina, in an urbanized landscape.                                                 Budischak SA, Hester JM, Price SJ, and Dorcas ME.                                                                               Southeastern Naturalist.  2006; 5:191-204.

Schantel (Hayes) Bouknight (2010 Graduate)

Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11.
Gregory-Bryson E, Bartlett E, Kiupel M, Hayes S, Yuzbasiyan-Gurkan V.
BMC Cancer. 2010 Oct 15;10:559.
PMID: 20950418

Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1.
Di Pietro N, Panel V, Hayes S, Bagattin A, Meruvu S, Pandolfi A, Hugendubler L, Fejes-Toth G, Naray-Fejes-Toth A, Mueller E.
Mol Endocrinol. 2010 Feb;24(2):370-80. Epub 2009 Dec 4.
PMID: 19965929

B-cell lymphoma in the peripheral nerves of a cat.
Higgins MA, Rossmeisl JH Jr, Saunders GK, Hayes S, Kiupel M.
Vet Pathol. 2008 Jan;45(1):54-7.
PMID: 18192576

Mark Hoenerhoff (2008 Graduate)

Kras, Egfr, and Tp53 Mutations in B6C3F1/N Mouse and F344/NTac Rat Alveolar/Bronchiolar Carcinomas Resulting from Chronic Inhalation Exposure to Cobalt Metal.

Hong HH, Hoenerhoff MJ, Ton TV, Herbert RA, Kissling GE, Hooth MJ, Behl M, Witt KL, Smith-Roe SL, Sills RC, Pandiri AR.

Toxicol Pathol. 2015 Jun 9. pii: 0192623315581192. [Epub ahead of print]

PMID: 26059825

F344/NTac Rats Chronically Exposed to Bromodichloroacetic Acid Develop Mammary Adenocarcinomas With Mixed Luminal/Basal Phenotype and Tgfβ Dysregulation.

Harvey JB, Hong HH, Bhusari S, Ton TV, Wang Y, Foley JF, Peddada SD, Hooth M, DeVito M, Nyska A, Pandiri AR, Hoenerhoff MJ.

Vet Pathol. 2015 Mar 2. pii: 0300985815571680. [Epub ahead of print]

PMID: 25732176

Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required.

Filgo AJ, Quist EM, Hoenerhoff MJ, Brix AE, Kissling GE, Fenton SE.

Toxicol Pathol. 2014 Nov 14. pii: 0192623314558463. [Epub ahead of print]

PMID: 25398757

A Brief Overview of the 33rd Annual STP Symposium on the Translational Pathology: Relevance of Toxicologic Pathology to Human Health.

Hoenerhoff MJ, Silverman L, Francke S.

Toxicol Pathol. 2014 Oct 27. pii: 0192623314555525. [Epub ahead of print]

PMID: 2535192

Overview of the "Epigenetic End Points in Toxicologic Pathology and Relevance to Human Health" Session of the 2014 Society of Toxicologic Pathology Annual Symposium.

Hoenerhoff MJ, Hartke J.

Toxicol Pathol. 2014 Oct 20. pii: 0192623314553475. [Epub ahead of print]

PMID: 25330923

Hepatic Mitochondrial Alteration in CD-1 Mice Associated with Prenatal Exposures to Low Doses of Perfluorooctanoic Acid (PFOA).

Quist EM, Filgo AJ, Cummings CA, Kissling GE, Hoenerhoff MJ, Fenton SE.

Toxicol Pathol. 2014 Oct 16. pii: 0192623314551841. [Epub ahead of print]

PMID: 25326589

Distinguishing Cystic Degeneration from Other Aging Lesions in the Adrenal Cortex of Sprague-Dawley Rats.

Laast VA, Larsen T, Allison N, Hoenerhoff MJ, Boorman GA.

Toxicol Pathol. 2014 Jun 26;42(5):823-829. [Epub ahead of print]

PMID: 24970856


Gene Expression of Mesothelioma in Vinylidene Chloride-exposed F344/N Rats Reveal Immune Dysfunction, Tissue Damage, and Inflammation Pathways.

Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2014 Jun 23. pii: 0192623314537885. [Epub ahead of print]

PMID: 24958746

Combined SFK/MEK inhibition prevents metastatic outgrowth of dormant tumor cells.

El Touny LH, Vieira A, Mendoza A, Khanna C, Hoenerhoff MJ, Green JE.

J Clin Invest. 2014 Jan 2;124(1):156-68. doi: 10.1172/JCI70259. Epub 2013 Dec 9.

PMID: 24316974

Spontaneous Mesotheliomas in F344/N Rats Are Characterized by Dysregulation of Cellular Growth and Immune Function Pathways.

Blackshear PE, Pandiri AR, Ton TV, Clayton NP, Shockley KR, Peddada SD, Gerrish KE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2013 Aug 26. [Epub ahead of print]

PMID: 23980201

Mutation Spectra of Kras and Tp53 in Urethral and Lung Neoplasms in B6C3F1 Mice Treated with 3,3',4,4'-Tetrachloroazobenzene.

Bhusari S, Malarkey DE, Hong HH, Wang Y, Masinde T, Nolan M, Hooth MJ, Lea IA, Vasconcelos D, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2013 May 23. [Epub ahead of print]

PMID: 23703846

Hepatocellular carcinomas in B6C3F1 mice treated with Ginkgo biloba extract for two years differ from spontaneous liver tumors in cancer gene mutations and genomic pathways.

Hoenerhoff MJ, Pandiri AR, Snyder SA, Hong HH, Ton TV, Peddada S, Shockley K, Witt K, Chan P, Rider C, Kooistra L, Nyska A, Sills RC.

Toxicol Pathol. 2013 Aug;41(6):826-41. doi: 10.1177/0192623312467520. Epub 2012 Dec 21.

PMID: 23262642

Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.

Pandiri AR, Sills RC, Ziglioli V, Ton TV, Hong HH, Lahousse SA, Gerrish KE, Auerbach SS, Shockley KR, Bushel PR, Peddada SD, Hoenerhoff MJ.

Toxicol Pathol. 2012 Dec;40(8):1141-59. doi: 10.1177/0192623312447543. Epub 2012 Jun 11.

PMID: 22688403

Inhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis.

Ray DM, Myers PH, Painter JT, Hoenerhoff MJ, Olden K, Roberts JD.

Br J Cancer. 2012 Jun 26;107(1):129-36. doi: 10.1038/bjc.2012.214. Epub 2012 May 29.

PMID: 22644295

Immunohistochemical investigation of F344/N rat islet cell tumors from national toxicology program studies.

Koivisto C, Flake GP, Kolenda-Roberts H, Masinde T, Kissling GE, Sills RC, Hoenerhoff MJ.

Toxicol Pathol. 2012 Jul;40(5):751-63. doi: 10.1177/0192623312441407. Epub 2012 Apr 3.

PMID: 22477723

Aloe vera non-decolorized whole leaf extract-induced large intestinal tumors in F344 rats share similar molecular pathways with human sporadic colorectal tumors.

Pandiri AR, Sills RC, Hoenerhoff MJ, Peddada SD, Ton TV, Hong HH, Flake GP, Malarkey DE, Olson GR, Pogribny IP, Walker NJ, Boudreau MD.

Toxicol Pathol. 2011 Dec;39(7):1065-74. doi: 10.1177/0192623311422081. Epub 2011 Sep 21.

PMID: 21937742

Global gene profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: similarities in the molecular landscape with human liver cancer.

Hoenerhoff MJ, Pandiri AR, Lahousse SA, Hong HH, Ton TV, Masinde T, Auerbach SS, Gerrish K, Bushel PR, Shockley KR, Peddada SD, Sills RC.

Toxicol Pathol. 2011 Jun;39(4):678-99. doi: 10.1177/0192623311407213. Epub 2011 May 13.

PMID: 21571946

Capacity for resolution of Ras-MAPK-initiated early pathogenic myocardial hypertrophy modeled in mice.

Wei BR, Martin PL, Hoover SB, Spehalski E, Kumar M, Hoenerhoff MJ, Rozenberg J, Vinson C, Simpson RM.

Comp Med. 2011 Apr;61(2):109-18.

PMID: 21535921

Evaluation of dosages and routes of administration of tramadol analgesia in rats using hot-plate and tail-flick tests.
Cannon CZ, Kissling GE, Hoenerhoff MJ, King-Herbert AP, Blankenship-Paris T.
Lab Anim (NY). 2010 Nov;39(11):342-51.
PMID: 20962760

Pathologic progression of mammary carcinomas in a C3(1)/SV40 T/t-antigen transgenic rat model of human triple-negative and Her2-positive breast cancer.
Hoenerhoff MJ, Shibata MA, Bode A, Green JE.
Transgenic Res. 2010 Jun 12. [Epub ahead of print]
PMID: 20549348

Left-sided cardiac valvulitis in tristetraprolin-deficient mice: the role of tumor necrosis factor alpha.
Ghosh S, Hoenerhoff MJ, Clayton N, Myers P, Stumpo DJ, Maronpot RR, Blackshear PJ.
Am J Pathol. 2010 Mar;176(3):1484-93. Epub 2010 Jan 21.
PMID: 20093488

A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer.
Hoenerhoff MJ, Hong HH, Ton TV, Lahousse SA, Sills RC.
Toxicol Pathol. 2009;37(7):835-48. Epub . Review.
PMID: 19846892

BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Hoenerhoff MJ, Chu I, Barkan D, Liu ZY, Datta S, Dimri GP, Green JE.
Oncogene. 2009 Aug 27;28(34):3022-32. Epub 2009 Jun 22.
PMID: 19543317

Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways.
Datta S, Hoenerhoff MJ, Bommi P, Sainger R, Guo WJ, Dimri M, Band H, Band V, Green JE, Dimri GP.
Cancer Res. 2007 Nov 1;67(21):10286-95.
PMID: 17974970

Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis.
Deeb KK, Michalowska AM, Yoon CY, Krummey SM, Hoenerhoff MJ, Kavanaugh C, Li MC, Demayo FJ, Linnoila I, Deng CX, Lee EY, Medina D, Shih JH, Green JE.
Cancer Res. 2007 Sep 1;67(17):8065-80. Erratum in: Cancer Res. 2007 Oct 15;67(20):10097.
PMID: 17804718

Fatal herpesvirus encephalitis in a reticulated giraffe (Giraffa camelopardalis reticulata).
Hoenerhoff MJ, Janovitz EB, Richman LK, Murphy DA, Butler TC, Kiupel M.
Vet Pathol. 2006 Sep;43(5):769-72.
PMID: 16966458

Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice.
Hoenerhoff MJ, Starost MF, Ward JM.
Vet Pathol. 2006 Sep;43(5):682-8.
PMID: 16966445

Choroid plexus papilloma in a Scottish highland cow.
Hoenerhoff MJ, Janovitz E, Ramos-Vara J, Kiupel M.
J Comp Pathol. 2006 Aug-Oct;135(2-3):146-9. Epub 2006 Sep 6.
PMID: 16952368

Multipotential osteosarcoma with various mesenchymal differentiations in a young dog.
Hoenerhoff MJ, Kiupel M, Rosenstein D, Pool RR.
Vet Pathol. 2004 May;41(3):264-8.
PMID: 15133175

Yava Jones-Hall (2010 Graduate)

Correction: Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.

Jones-Hall YL, Kozik A, Nakatsu C.

PLoS One. 2015 Apr 10;10(4):e0125309. doi: 10.1371/journal.pone.0125309. eCollection 2015.

PMID: 25860670

Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.

Jones-Hall YL, Kozik A, Nakatsu C.

PLoS One. 2015 Apr 10;10(4):e0125309. doi: 10.1371/journal.pone.0125309. eCollection 2015.

PMID: 25860670

Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease.

Jones-Hall YL, Grisham MB.

Pathophysiology. 2014 May 27. pii: S0928-4680(14)00027-3. doi: 10.1016/j.pathophys.2014.05.002. [Epub ahead of print] Review.

PMID: 24935242


Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study.

Li C, Wei R, Jones-Hall YL, Vittal R, Zhang M, Liu W.

Sci Rep. 2014 May 13;4:4893. doi: 10.1038/srep04893.

PMID: 24819665

Association between MUC5B and TERT polymorphisms and different interstitial lung disease phenotypes.

Wei R, Li C, Zhang M, Jones-Hall YL, Myers JL, Noth I, Liu W.

Transl Res. 2013 Dec 17. pii: S1931-5244(13)00438-6. doi: 10.1016/j.trsl.2013.12.006.

PMID: 24434656

Characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on DMBA-induced mammary tumorigenesis in mice.

Siddiqui RA, Harvey KA, Walker C, Altenburg J, Xu Z, Terry C, Camarillo I, Jones-Hall Y, Mariash C.

BMC Cancer. 2013 Sep 13;13:418. doi: 10.1186/1471-2407-13-418.

PMID: 24034496

Association between hTERT rs2736100 polymorphism and sensitivity to anti-cancer agents.

Kim J, Jones-Hall YL, Wei R, Myers J, Qi Y, Knipp GT, Liu W.

Front Genet. 2013 Aug 26;4:162. doi: 10.3389/fgene.2013.00162. eCollection 2013.

PMID: 23986774

Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin.

Saud SM, Young MR, Jones-Hall YL, Ileva L, Evbuomwan MO, Wise J, Colburn NH, Kim YS, Bobe G.

Cancer Res. 2013 Sep 1;73(17):5473-84. doi: 10.1158/0008-5472.CAN-13-0525. Epub 2013 Jul 1.

PMID: 23824743

LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.

Orr SJ, Burg AR, Chan T, Quigley L, Jones GW, Ford JW, Hodge D, Razzook C, Sarhan J, Jones YL, Whittaker GC, Boelte KC, Lyakh L, Cardone M, O'Connor GM, Tan C, Li H, Anderson SK, Jones SA, Zhang W, Taylor PR, Trinchieri G, McVicar DW.  PLoS Pathog. 2013 May;9(5):e1003357. doi: 10.1371/journal.ppat.1003357. Epub 2013 May 9.

PMID: 23675302

Tissue expression of steroid hormone receptors is associated with differential immune responsiveness.
Butts CL, Jones YL, Lim JK, Salter CE, Belyavskaya E, Sternberg EM.
Brain Behav Immun. 2010 Nov 11. [Epub ahead of print]
PMID: 21074604

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18.
Salcedo R, Worschech A, Cardone M, Jones Y, Gyulai Z, Dai RM, Wang E, Ma W, Haines D, O'hUigin C, Marincola FM, Trinchieri G.
J Exp Med. 2010 Aug 2;207(8):1625-36. Epub 2010 Jul 12.
PMID: 20624890

Articular gout and suspected pseudogout in a Basilisk lizard (Basilicus plumifrons).
Jones YL, Fitzgerald SD.
J Zoo Wildl Med. 2009 Sep;40(3):576-8.
PMID: 19746877

Monitoring of tumor promotion and progression in a mouse model of inflammation-induced colon cancer with magnetic resonance colonography.
Young MR, Ileva LV, Bernardo M, Riffle LA, Jones YL, Kim YS, Colburn NH, Choyke PL.
Neoplasia. 2009 Mar;11(3):237-46, 1p following 246.
PMID: 19242605

Uveal spindle cell tumor of blue-eyed dogs: an immunohistochemical study.
Zarfoss MK, Klauss G, Newkirk K, Kiupel M, Jones Y, Colitz CM, Dubielzig RR.
Vet Pathol. 2007 May;44(3):276-84.
PMID: 17491068

Toxoplasmosis in a free-ranging mink.
Jones YL, Fitzgerald SD, Sikarske JG, Murphy A, Grosjean N, Kiupel M.
J Wildl Dis. 2006 Oct;42(4):865-9.
PMID: 17255457

Peliod hepatocellular carcinoma in a domesticated ferret (Mustela putorius furo).
Jones Y, Wise A, Maes R, Kiupel M.
J Vet Diagn Invest. 2006 Mar;18(2):228-31.
PMID: 16617711


Tiffany (Reed) Lyle (2016 Graduate)

Alterations in Pericyte Subpopulations are Associated with Elevated Blood-Tumor Barrier Permeability in Experimental Brain Metastasis of Breast Cancer.

Lyle LT, Lockman PR, Adkins CE, Mohammad AS, Sechrest E, Hua E, Palmieri D, Liewehr DJ, Steinberg SM, Kloc W, Izycka-Swieszewska E, Duchnowska R, Nayyar N, Brastianos PK, Steeg PS, Gril B.

Clin Cancer Res. 2016 May 31. pii: clincanres.1836.2015. [Epub ahead of print]

PMID: 27245829

Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.

Hernandez L, Kim MK, Lyle LT, Bunch KP, House CD, Ning F, Noonan AM, Annunziata CM.  Gynecol Oncol. 2016 Aug;142(2):332-40. doi: 10.1016/j.ygyno.2016.05.028. Epub 2016 May 28.

PMID: 27235858

DNA double-strand break repair genes and oxidative damage in brain metastasis of breast cancer.

Woditschka S, Evans L, Duchnowska R, Reed LT, Palmieri D, Qian Y, Badve S, Sledge G Jr, Gril B, Aladjem MI, Fu H, Flores NM, Gökmen-Polar Y, Biernat W, Szutowicz-Zieli?ska E, Mandat T, Trojanowski T, Och W, Czartoryska-Arlukowicz B, Jassem J, Mitchell JB, Steeg PS.

J Natl Cancer Inst. 2014 Jun 19;106(7). pii: dju145. doi: 10.1093/jnci/dju145. Print 2014 Jul.

PMID: 24948741

Breast cancer metastasis: issues for the personalization of its prevention and treatment.
Marino N, Woditschka S, Reed LT, Nakayama J, Mayer M, Wetzel M, Steeg PS.
Am J Pathol. 2013 Oct;183(4):1084-95. doi: 10.1016/j.ajpath.2013.06.012. Epub 2013 Jul 26.
PMID: 23895915

“Central Nervous System Metastasis, The Biological Basis and Clinical Considerations.”  

Woditschka S, Gril B, Evans L, Reed LT, Steeg P. 

Cancer Metastasis –Biology and Treatment: The Molecular Biology of Brain Metastases. 

Ed. Palmieri D. Dordrecht: Springer, 2012. 18 (15-41).

Cutaneous Metastasis of Transitional Cell Carcinoma in 12 Dogs.  

Reed LT, Knapp DW, Miller MA. 

Vet Pathol. 2012 Nov 6 [Epub ahead of print] 

PMID: 23136183

Diagnostic exercise: cerebral mass in a puppy with respiratory distress and progressive neurologic signs.
Reed LT, Miller MA, Visvesvara GS, Gardiner CH, Logan MA, Packer RA.
Vet Pathol. 2010 Nov;47(6):1116-9. Epub 2010 Jul 15.
PMID: 20634413

Pathology in practice. Granulomatous pneumonia, prostatitis and uveitis with intralesional yeasts consistent with Blastomyces.
Reed LT, Balog KA, Boes KM, Messick JB, Miller MA.
J Am Vet Med Assoc. 2010 Feb 15;236(4):411-3. No abstract available.
PMID: 20151862

Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
Wei BR, Edwards JB, Hoover SB, Tillman HS, Reed LT, Sills RC, Simpson RM.
Toxicol Pathol. 2008;36(7):972-80. Epub 2008 Oct 31.
PMID: 18978308


Philip Martin  (2014 Graduate)

A preclinical orthotopic model for glioblastoma recapitulates key features of human tumors and demonstrates sensitivity to a combination of MEK and PI3K pathway inhibitors.

El Meskini R, Iacovelli AJ, Kulaga A, Gumprecht M, Martin PL, Baran M, Householder DB, Van Dyke T, Weaver Ohler Z.

Dis Model Mech. 2015 Jan;8(1):45-56. doi: 10.1242/dmm.018168. Epub 2014 Nov 27.

PMID: 25431423

"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.

Day CP, Carter J, Weaver Ohler Z, Bonomi C, El Meskini R, Martin P, Graff-Cherry C, Feigenbaum L, Tüting T, Van Dyke T, Hollingshead M, Merlino G.

PLoS One. 2014 Nov 4;9(11):e109956. doi: 10.1371/journal.pone.0109956. eCollection 2014.

PMID: 25369133

Vitamin d receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy.

Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, Collisson EA, Connor F, Van Dyke T, Kozlov S, Martin P, Tseng TW, Dawson DW, Donahue TR, Masamune A, Shimosegawa T, Apte MV, Wilson JS, Ng B, Lau SL, Gunton JE, Wahl GM, Hunter T, Drebin JA, O'Dwyer PJ, Liddle C, Tuveson DA, Downes M, Evans RM.

Cell. 2014 Sep 25;159(1):80-93. doi: 10.1016/j.cell.2014.08.007.

PMID: 24748377

Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer.

Szabova L, Bupp S, Kamal M, Householder DB, Hernandez L, Schlomer JJ, Baran ML, Yi M, Stephens RM, Annunziata CM, Martin PL, Van Dyke TA, Weaver Ohler Z, Difilippantonio S.

PLoS One. 2014 Apr 18;9(4):e95649. doi: 10.1371/journal.pone.0095649. eCollection 2014.

PMID: 24748377

Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, Simons BW, Ward JM, Robinson BD, Chu GC, Loda M, Thomas G, Borowsky A, Cardiff RD.

Cancer Res. 2013 May 1;73(9):2718-36. doi: 10.1158/0008-5472.CAN-12-4213. Epub 2013 Apr 22.

PMID: 23610450

Carcinoma Initiation via Rb Tumor Suppressor Inactivation: A Versatile Approach to Epithelial Subtype-Dependent Cancer Initiation in Diverse Tissues.

Song Y, Gilbert D, O'Sullivan TN, Yang C, Pan W, Fathalizadeh A, Lu L, Haines DC, Martin PL, Van Dyke T.

PLoS One. 2013 Dec 2;8(12):e80459. doi: 10.1371/journal.pone.0080459. eCollection 2013.

PMID: 24312475

MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.

Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K.

Oncogene. 2013 Jan 17;32(3):296-306. doi: 10.1038/onc.2012.58. Epub 2012 Feb 27.

PMID: 22370643

Temporal molecular and biological assessment of an erlotinib-resistant lung adenocarcinoma model reveals markers of tumor progression and treatment response.

Weaver Z, Difilippantonio S, Carretero J, Martin PL, El Meskini R, Iacovelli AJ, Gumprecht M, Kulaga A, Guerin T, Schlomer J, Baran M, Kozlov S, McCann T, Mena S, Al-Shahrour F, Alexander D, Wong KK, Van Dyke T.

Cancer Res. 2012 Nov 15;72(22):5921-33. doi: 10.1158/0008-5472.CAN-12-0736. Epub 2012 Sep 11.

PMID: 22969147

TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.

Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.

PLoS One. 2012;7(7):e41668. doi: 10.1371/journal.pone.0041668. Epub 2012 Jul 30.

PMID: 22860005

CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model.

Ward Y, Lake R, Martin PL, Killian K, Salerno P, Wang T, Meltzer P, Merino M, Cheng SY, Santoro M, Garcia-Rostan G, Kelly K.

Oncogene. 2013 May 30;32(22):2726-38. doi: 10.1038/onc.2012.301. Epub 2012 Jul 16.

PMID: 22797060

Perturbation of Rb, p53, and Brca1 or Brca2 cooperate in inducing metastatic serous epithelial ovarian cancer.

Szabova L, Yin C, Bupp S, Guerin TM, Schlomer JJ, Householder DB, Baran ML, Yi M, Song Y, Sun W, McDunn JE, Martin PL, Van Dyke T, Difilippantonio S

Cancer Res. 2012 Aug 15;72(16):4141-53. doi: 10.1158/0008-5472.CAN-11-3834. Epub 2012 May 22.

PMID: 22617326

Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.

Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.

Mol Cell Biol. 2012 Mar;32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27.

PMID: 22203039

Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.

Abou-Kheir W, Hynes PG, Martin P, Yin JJ, Liu YN, Seng V, Lake R, Spurrier J, Kelly K.

PLoS One. 2011;6(10):e26112. doi: 10.1371/journal.pone.0026112. Epub 2011 Oct 11.

PMID: 22022528

Compatibility of H9N2 avian influenza surface genes and 2009 pandemic H1N1 internal genes for transmission in the ferret model.

Kimble JB, Sorrell E, Shao H, Martin PL, Perez DR.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12084-8. doi: 10.1073/pnas.1108058108. Epub 2011,Jul 5.

PMID: 21730147

Prostate epithelial Pten/TP53 loss leads to transformation of multipotential progenitors and epithelial to mesenchymal transition.

Martin P, Liu YN, Pierce R, Abou-Kheir W, Casey O, Seng V, Camacho D, Simpson RM, Kelly K.

Am J Pathol. 2011 Jul;179(1):422-35. doi: 10.1016/j.ajpath.2011.03.035. Epub 2011 May 13.

PMID: 21703421

Capacity for resolution of Ras-MAPK-initiated early pathogenic myocardial hypertrophy modeled in mice.

Wei BR, Martin PL, Hoover SB, Spehalski E, Kumar M, Hoenerhoff MJ, Rozenberg J, Vinson C, Simpson RM.

Comp Med. 2011 Apr;61(2):109-18.

PMID: 21535921

Characterizing the Contribution of Stem/Progenitor Cells to Tumorigenesis in the Pten(-/-)TP53(-/-) Prostate Cancer Model.
Abou-Kheir WG, Hynes PG, Martin PL, Pierce R, Kelly K.
Stem Cells. 2010 Oct 8.

PMID: 20936707

Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.

Yin J, Pollock C, Tracy K, Chock M, Martin P, Oberst M, Kelly K.

Mol Cell Biol. 2007 Nov;27(21):7538-50. Epub 2007 Aug 20.

PMID: 17709381

Ian Moore (2014 Graduate)

Severity of clinical disease and pathology in ferrets experimentally infected with influenza viruses is influenced by inoculum volume.                                                                                                                                     

Moore IN, Lamirande EW, Paskel M, Donahue D, Qin J, Subbarao K.

J Virol. 2014  Dec;88(23):13879-91. doi: 10.1128/JVI.02341-14. Epub 2014 Sep 3.

PMID: 25187553

Enteric Colonization by Staphylococcus delphini in Four Ferret Kits with Diarrhoea.                                            

Gary JM, Langohr IM, Lim A, Bolin S, Bolin C, Moore I, Kiupel M.

J Comp Pathol. 2014 Nov;151(4):314-7. doi: 10.1016/j.jcpa.2014.08.004. Epub 2014 Sep 22.

PMID: 25246181

Receptor specificity does not affect replication or virulence of the 2009 pandemic H1N1 influenza virus in mice and ferrets.

Lakdawala SS, Shih AR, Jayaraman A, Lamirande EW, Moore I, Paskel M, Sasisekharan R, Subbarao K.

Virology. 2013 Nov;446(1-2):349-56. doi: 10.1016/j.virol.2013.08.011. Epub 2013 Sep 10.

PMID: 24074599

Tanasa Osborne (2010 Graduate)

Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease.

Wahlang B, Song M, Beier JI, Cameron Falkner K, Al-Eryani L, Clair HB, Prough RA, Osborne TS, Malarkey DE, Christopher States J, Cave MC.

Toxicol Appl Pharmacol. 2014 Jul 3. pii: S0041-008X(14)00248-8. doi: 10.1016/j.taap.2014.06.019. [Epub ahead of print]  PMID: 24998970

PMID: 24998970

A review of the association between osteosarcoma metastasis and protein translation.

Osborne TS, Khanna C.

J Comp Pathol. 2012 Feb-Apr;146(2-3):132-42. doi: 10.1016/j.jcpa.2011.12.007. Epub 2012 Jan 31. Review.

PMID: 22297074

Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray.

Osborne TS, Ren L, Healey JH, Shapiro LQ, Chou AJ, Gorlick RG, Hewitt SM, Khanna C.

J Pediatr Hematol Oncol. 2011 Oct;33(7):524-8. doi: 10.1097/MPH.0b013e318223d0c1.

PMID: 21941146

Protein kinase C regulates ezrin-radixin-moesin phosphorylation in canine osteosarcoma cells.

Hong SH, Osborne T, Ren L, Briggs J, Mazcko C, Burkett SS, Khanna C.

Vet Comp Oncol. 2011 Sep;9(3):207-18. doi: 10.1111/j.1476-5829.2010.00249.x. Epub 2010 Dec 14.

PMID: 21848623

Modeling metastasis biology and therapy in real time in the mouse lung.
Mendoza A, Hong SH, Osborne T, Khan MA, Campbell K, Briggs J, Eleswarapu A, Buquo L, Ren L, Hewitt SM, Dakir el H, Garfield S, Walker R, Merlino G, Green JE, Hunter KW, Wakefield LM, Khanna C.
J Clin Invest. 2010 Aug 2;120(8):2979-88. doi: 10.1172/JCI40252. Epub 2010 Jul 19. Erratum in: J Clin Invest. 2010 Oct 1;120(10):3735. Dakir, el-H [corrected to Dakir, El Habib].
PMID: 20644255

Rapamycin pharmacokinetic and pharmacodynamic relationships in osteosarcoma: a comparative oncology study in dogs.
Paoloni MC, Mazcko C, Fox E, Fan T, Lana S, Kisseberth W, Vail DM, Nuckolls K, Osborne T, Yalkowsy S, Gustafson D, Yu Y, Cao L, Khanna C.
PLoS One. 2010 Jun 8;5(6):e11013.
PMID: 20543980

Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma.
Abdeen A, Chou AJ, Healey JH, Khanna C, Osborne TS, Hewitt SM, Kim M, Wang D, Moody K, Gorlick R.
Cancer. 2009 Nov 15;115(22):5243-50.
PMID: 19670450

The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC.
Ren L, Hong SH, Cassavaugh J, Osborne T, Chou AJ, Kim SY, Gorlick R, Hewitt SM, Khanna C.
Oncogene. 2009 Feb 12;28(6):792-802. Epub 2008 Dec 8.
PMID: 19060919

Heather Shive (2010 Graduate)

Expression of KRASG12V in Zebrafish Gills Induces Hyperplasia and CXCL8-Associated Inflammation.

Shive HR, West RR, Embree LJ, Sexton JM, Hickstein DD.

Zebrafish. 2015 Jun;12(3):221-9. doi: 10.1089/zeb.2014.1038. Epub 2015 Mar 23.

PMID: 25798815

Evaluation of the contributions of the individual viral genes to Newcastle disease virus virulence and pathogenesis.

Paldurai A, Kim SH, Nayak B, Xiao S, Shive H, Collins PL, Samal SK.

J Virol. 2014 May 21. pii: JVI.00666-14. [Epub ahead of print]

PMID: 24850737

brca2 and tp53 Collaborate in Tumorigenesis in Zebrafish.

Shive HR, West RR, Embree LJ, Golden CD, Hickstein DD.

PLoS One. 2014 Jan 29;9(1):e87177. doi: 10.1371/journal.pone.0087177. eCollection 2014.

PMID: 24489863

Long-term follow-up of foamy viral vector-mediated gene therapy for canine leukocyte adhesion deficiency.

Bauer TR Jr, Tuschong LM, Calvo KR, Shive HR, Burkholder TH, Karlsson EK, West RR, Russell DW, Hickstein DD.

Mol Ther. 2013 May;21(5):964-72. doi: 10.1038/mt.2013.34. Epub 2013 Mar 26.

PMID: 23531552

Mutations in the fusion protein cleavage site of avian paramyxovirus serotype 4 confer increased replication and syncytium formation in vitro but not increased replication and pathogenicity in chickens and ducks.

Kim SH, Xiao S, Shive H, Collins PL, Samal SK.

PLoS One. 2013;8(1):e50598. doi: 10.1371/journal.pone.0050598. Epub 2013 Jan 14.

PMID: 23341874

Zebrafish models for human cancer.

Shive HR.

Vet Pathol. 2013 May;50(3):468-82. doi: 10.1177/0300985812467471. Epub 2012 Nov 30.

PMID: 23203679

Replication, neurotropism, and pathogenicity of avian paramyxovirus serotypes 1-9 in chickens and ducks.

Kim SH, Xiao S, Shive H, Collins PL, Samal SK.

PLoS One. 2012;7(4):e34927. doi: 10.1371/journal.pone.0034927. Epub 2012 Apr 30.

PMID: 22558104

Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.

Wei BR, Simpson RM, Johann DJ, Dwyer JE, Prieto DA, Kumar M, Ye X, Luke B, Shive HR, Webster JD, Hoover SB, Veenstra TD, Blonder J.

J Proteome Res. 2012 Mar 2;11(3):1561-70. doi: 10.1021/pr200612y. Epub 2012 Feb 6.

PMID: 22214408

Experimental infection of hamsters with avian paramyxovirus serotypes 1 to 9.

Samuel AS, Subbiah M, Shive H, Collins PL, Samal SK.

Vet Res. 2011 Feb 23;42:38. doi: 10.1186/1297-9716-42-38.

PMID: 21345199

brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis.
Shive HR, West RR, Embree LJ, Azuma M, Sood R, Liu P, Hickstein DD.
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5. Epub 2010 Oct 25.
PMID: 20974951

Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever.
Russell-Lodrigue KE, Andoh M, Poels MW, Shive HR, Weeks BR, Zhang GQ, Tersteeg C, Masegi T, Hotta A, Yamaguchi T, Fukushi H, Hirai K, McMurray DN, Samuel JE.
Infect Immun. 2009 Dec;77(12):5640-50. Epub 2009 Sep 28.
PMID: 19786560

T cells are essential for bacterial clearance, and gamma interferon, tumor necrosis factor alpha, and B cells are crucial for disease development in Coxiella burnetii infection in mice.
Andoh M, Zhang G, Russell-Lodrigue KE, Shive HR, Weeks BR, Samuel JE.
Infect Immun. 2007 Jul;75(7):3245-55. Epub 2007 Apr 16.
PMID: 17438029

Heather Tillman

Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors.

Agarwal S, Hynes PG, Tillman HS, Lake R, Abou-Kheir WG, Fang L, Casey OM, Ameri AH, Martin PL, Yin JJ, Iaquinta PJ, Karthaus WR, Clevers HC, Sawyers CL, Kelly K.

Cell Rep. 2015 Dec 15;13(10):2147-58. doi: 10.1016/j.celrep.2015.10.077. Epub 2015 Nov 25.

PMID: 26628377

EGF receptor promotes prostate cancer bone metastasis by downregulating miR-1 and activating TWIST1.

Chang YS, Chen WY, Yin JJ, Tillman H, Huang J, Liu YN.

Cancer Res. 2015 Jun 12. pii: canres.3380.2014. [Epub ahead of print]

PMID: 26071255

Loss of Androgen-Regulated MicroRNA 1 Activates SRC and Promotes Prostate Cancer Bone Metastasis.

Liu YN, Yin J, Barrett B, Sheppard-Tillman H, Li D, Casey OM, Fang L, Hynes PG, Ameri AH, Kelly K.

Mol Cell Biol. 2015 Jun 1;35(11):1940-51. doi: 10.1128/MCB.00008-15. Epub 2015 Mar 23.

PMID: 25802280

AR-regulated TWEAK-FN14 pathway promotes prostate cancer bone metastasis.

 Yin J*, Liu YN*, Tillman H*, Barrett B, Hewitt S, Ylaya K, Fang L, Lake R, Corey E, Morrissey C, Vessella R, Kelly K.

Cancer Res. 2014 Aug 15;74(16):4306-17. doi: 10.1158/0008-5472.CAN-13-3233. Epub 2014 Jun 26.

PMID: 24970477  *Equally contributed to this work.

MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, Yi M, Stephens RM, Seng V, Sheppard-Tillman H, Martin P, Kelly K.
Oncogene. 2013 Jan 17;32(3):296-306. doi: 10.1038/onc.2012.58. Epub 2012 Feb 27.
PMID: 22370643  

Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor β-initiated prostate cancer epithelial-mesenchymal transition.

Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, Hu D, Wan Y, Seng V, Sheppard-Tillman H, Martin P, Kelly K.      Mol Cell Biol. 2012 Mar;32(5):941-53. doi: 10.1128/MCB.06306-11. Epub 2011 Dec 27.                                                    PMID: 22203039                                                     

TMPRSS2- driven ERG expression in vivo increases self-renewal and maintains expression in a castration resistant subpopulation.

Casey OM, Fang L, Hynes PG, Abou-Kheir WG, Martin PL, Tillman HS, Petrovics G, Awwad HO, Ward Y, Lake R, Zhang L, Kelly K.  PLoS One. 2012;7(7):e41668. doi: 10.1371/journal.pone.0041668. Epub 2012 Jul 30.

PMID: 22860005

Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques.
Wei BR, Edwards JB, Hoover SB, Tillman HS, Reed LT, Sills RC, Simpson RM.
Toxicol Pathol. 2008;36(7):972-80. Epub 2008 Oct 31.
PMID: 18978308

Protein expression profiling of normal and neoplastic canine prostate and bladder tissue.
LeRoy B, Painter A, Sheppard H, Popiolek L, Samuel-Foo M, Andacht TM.
Vet Comp Oncol. 2007 Jun;5(2):119-30.
PMID: 19754795

Kevin Woolard (2010 Graduate)

Characterization of the temporomandibular joint of the harbour porpoise (Phocoena phocoena) and Risso's dolphin (Grampus griseus).

McDonald M, Vapniarsky-Arzi N, Verstraete FJ, Staszyk C, Leale DM, Woolard KD, Arzi B.

Arch Oral Biol. 2015 Apr;60(4):582-92. doi: 10.1016/j.archoralbio.2015.01.005. Epub 2015 Jan 9.

PMID: 25617743

Identification of a polyomavirus microRNA highly expressed in tumors.

Chen CJ, Cox JE, Azarm KD, Wylie KN, Woolard KD, Pesavento PA, Sullivan CS.

Virology. 2014 Dec 12;476C:43-53. doi: 10.1016/j.virol.2014.11.021. [Epub ahead of print]

PMID: 25514573

Identification of molecular pathways facilitating glioma cell invasion in situ.

Nevo I, Woolard K, Cam M, Li A, Webster JD, Kotliarov Y, Kim HS, Ahn S, Walling J, Kotliarova S, Belova G, Song H, Bailey R, Zhang W, Fine HA.

PLoS One. 2014 Nov 3;9(11):e111783. doi: 10.1371/journal.pone.0111783. eCollection 2014.

PMID: 25365423

The raccoon polyomavirus genome and tumor antigen transcription are stable and abundant in neuroglial tumors.

Brostoff T, Dela Cruz FN Jr, Church ME, Woolard KD, Pesavento PA.

J Virol. 2014 Nov;88(21):12816-24. doi: 10.1128/JVI.01912-14. Epub 2014 Aug 27.

PMID: 25165109

Micro-environment causes reversible changes in DNA methylation and mRNA expression profiles in patient-derived glioma stem cells.

Baysan M, Woolard K, Bozdag S, Riddick G, Kotliarova S, Cam MC, Belova GI, Ahn S, Zhang W, Song H, Walling J, Stevenson H, Meltzer P, Fine HA.

PLoS One. 2014 Apr 11;9(4):e94045. doi: 10.1371/journal.pone.0094045. eCollection 2014.

PMID: 24728236

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State.

Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG.

Cell Rep. 2014 Jan 30;6(2):313-24. doi: 10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16.

PMID: 24440720

Histone demethylase Jumonji D3 (JMJD3) as a tumor suppressor by regulating p53 protein nuclear stabilization.

Ene CI, Edwards L, Riddick G, Baysan M, Woolard K, Kotliarova S, Lai C, Belova G, Cam M, Walling J, Zhou M, Stevenson H, Kim HS, Killian K, Veenstra T, Bailey R, Song H, Zhang W, Fine HA.

PLoS One. 2012;7(12):e51407. doi: 10.1371/journal.pone.0051407. Epub 2012 Dec 7.

PMID: 23236496

Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim HS, Woolard K, Lai C, Bauer PO, Maric D, Song H, Li A, Kotliarova S, Zhang W, Fine HA.

Cancer Res. 2012 Nov 15;72(22):6065-75. doi: 10.1158/0008-5472.CAN-12-2594. Epub 2012 Sep 17.

PMID: 22986743

Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma.

Morgan RA, Johnson LA, Davis JL, Zheng Z, Woolard KD, Reap EA, Feldman SA, Chinnasamy N, Kuan CT, Song H, Zhang W, Fine HA, Rosenberg SA.

Hum Gene Ther. 2012 Oct;23(10):1043-53. doi: 10.1089/hum.2012.041. Epub 2012 Sep 24.

PMID: 22780919

Effect of brain- and tumor-derived connective tissue growth factor on glioma invasion.

Edwards LA, Woolard K, Son MJ, Li A, Lee J, Ene C, Mantey SA, Maric D, Song H, Belova G, Jensen RT, Zhang W, Fine HA.

J Natl Cancer Inst. 2011 Aug 3;103(15):1162-78. doi: 10.1093/jnci/djr224. Epub 2011 Jul 19.

PMID: 21771732

Serum S100A6 concentration predicts peritoneal tumor burden in mice with epithelial ovarian cancer and is associated with advanced stage in patients.
Wei BR, Hoover SB, Ross MM, Zhou W, Meani F, Edwards JB, Spehalski EI, Risinger JI,
Alvord WG, Quinones OA, Belluco C, Martella L, Campagnutta E, Ravaggi A, Dai RM,
Goldsmith PK, Woolard KD, Pecorelli S, Liotta LA, Petricoin EF, Simpson RM.
PLoS One. 2009 Oct 30;4(10):e7670.
PMID: 19888321

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.
Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. Epub 2009 Aug 10.
PMID: 19667175

Glioma stem cells: better flat than round.
Woolard K, Fine HA.
Cell Stem Cell. 2009 Jun 5;4(6):466-7.
PMID: 19497271

SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma.
Son MJ, Woolard K, Nam DH, Lee J, Fine HA.
Cell Stem Cell. 2009 May 8;4(5):440-52.
PMID: 19427293

Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells.
Lee J, Son MJ, Woolard K, Donin NM, Li A, Cheng CH, Kotliarova S, Kotliarov Y, Walling J, Ahn S, Kim M, Totonchy M, Cusack T, Ene C, Ma H, Su Q, Zenklusen JC, Zhang W, Maric D, Fine HA.
Cancer Cell. 2008 Jan;13(1):69-80.
PMID: 18167341

Clearance of a dermal Huffmanela sp. in a sandbar shark (Carcharhinus plumbeus) using levamisole. MacLean RA, Fatzinger MH, Woolard KD, Harms CA.
Dis Aquat Organ. 2006 Nov 21;73(1):83-8.
PMID: 17240757

Leah Zadrozny (2015 Graduate)

Study of the Development of the Mouse Thoracic Aorta Three-Dimensional Macromolecular Structure using Two-Photon Microscopy.

Zadrozny LM, Neufeld EB, Lucotte BM, Connelly PS, Yu ZX, Dao L, Hsu LY, Balaban RS.

J Histochem Cytochem. 2015 Jan;63(1):8-21. doi: 10.1369/0022155414559590. Epub 2014 Oct 31.

PMID: 25362141

Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.

Neufeld EB, Zadrozny LM, Phillips D, Aponte A, Yu ZX, Balaban RS.

Atherosclerosis. 2014 Mar;233(1):113-21. doi: 10.1016/j.atherosclerosis.2013.12.038. Epub 2014 Jan 8.

PMID: 24529131

Spontaneous hepatocellular carcinoma in captive prosimians.
Zadrozny LM, Williams CV, Remick AK, Cullen JM.
Vet Pathol. 2010 Mar;47(2):306-11. Epub 2009 Dec 31.
PMID: 20147584

5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats.
Elangbam CS, Job LE, Zadrozny LM, Barton JC, Yoon LW, Gates LD, Slocum N.
Exp Toxicol Pathol. 2008 Aug;60(4-5):253-62. Epub 2008 Jun 3.
PMID: 18511249

Neutrophils do not mediate the pathophysiological sequelae of Cryptosporidium parvum infection in neonatal piglets.
Zadrozny LM, Stauffer SH, Armstrong MU, Jones SL, Gookin JL.
Infect Immun. 2006 Oct;74(10):5497-505.
PMID: 16988224



Trainee Publications

Caroline Andrews

Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.

McLean MH, Andrews C, Hanson ML, Baseler WA, Anver MR, Senkevitch E, Staniszewska AK, Smith C, Davies LC, Hixon J, Li W, Shen W, Steidler L, Durum SK.

Inflamm Bowel Dis. 2017 Nov;23(11):1983-1995. doi: 10.1097/MIB.0000000000001274.

PMID: 29019857


Pathology in Practice. Pneumonia and hepatitis associated with ascarid larval migration.

Ducatti KR, Andrews C, Kazacos KR, Randall C, Langohr IM.

J Am Vet Med Assoc. 2017 Jul 1;251(1):61-64. doi: 10.2460/javma.251.1.61. No abstract available.

 PMID: 28621600

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice.

Shen W, Li W, Hixon JA, Andrews C, Durum SK.

J Vis Exp. 2017 Jan 25;(119). doi: 10.3791/54710.

PMID: 2819003

Interleukin-27 as a Novel Therapy for Inflammatory Bowel Disease: A Critical Review of the Literature.

Andrews C, McLean MH, Durum SK.

Inflamm Bowel Dis. 2016 Sep;22(9):2255-64. doi: 10.1097/MIB.0000000000000818.

PMID: 27243591

Cross Lineage Rearrangement in Feline Enteropathy-Associated T-cell Lymphoma.

Andrews C, Operacz M, Maes R, Kiupel M.

Vet Pathol. 2015 Jul 27. pii: 0300985815595518. [Epub ahead of print]

PMID: 26215761

Pathology in Practice: Pneumonia and hepatitis associated with ascarid larval migration in two pigs.

Ducatti KR, Andrews C, Kazacos K, Randall C, Langohr IM.

Accepted by Journal of the American Veterinary Medical Association May 13, 2015.

Pathology in Practice: compound odontoma in a horse.

Andrews C, Gadsden BJ, Carr EA, Kiupel M.

Journal of the American Veterinary Medical Association, Feb 15 244(4):  417-419.


Jessica Beck

Surfactant Protein A and Napsin A in the Immunohistochemical Characterization of Canine Pulmonary Carcinomas: Comparison With Thyroid Transcription Factor-1.

Beck J, Miller MA, Frank C, DuSold D, Ramos-Vara JA.

Vet Pathol. 2017 Sep;54(5):767-774. doi: 10.1177/0300985817712559. Epub 2017 Jun 5.

PMID: 28578631


Kara Corps

Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients.

LeBlanc AK, Mazcko C, Brown DE, Koehler JW, Miller AD, Miller CR, Bentley RT, Packer RA, Breen M, Boudreau CE, Levine JM, Simpson RM, Halsey C, Kisseberth W, Rossmeisl JH Jr, Dickinson PJ, Fan TM, Corps K, Aldape K, Puduvalli V, Pluhar GE, Gilbert MR.

Neuro Oncol. 2016 Sep;18(9):1209-18. doi: 10.1093/neuonc/now051. Epub 2016 May 14. Review.

PMID: 27179361

Inflammation and Neuroprotection in Traumatic Brain Injury.

Corps KN, Roth TL, McGavern DB.

JAMA Neurol. 2015 Jan 19. doi: 10.1001/jamaneurol.2014.3558.

PMID: 25599342

In vivo dynamics of innate immune sentinels in the CNS.                                                                                  Nayak D, Zinselmeyer B, Corps K, McGavern D.                                                                                        

Intravital 2012; 1:2, 95-106. 

Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis.

Webster JD, Michalowski AM, Dwyer JE, Corps KN, Wei BR, Juopperi T, Hoover SB, Simpson RM. 

J Pathol Inform. 2012;3:18. doi: 10.4103/2153-3539.95130. Epub 2012 Apr 18.

PMID: 22616030

Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury.
Corps KN, Islam Z, Pestka JJ, Harkema JR.
Toxicol Pathol. 2010;38(3):429-51.
PMID: 20430879

Veterinarians in biomedical research: building national capacity.
Buss DD, Atchison ML, Corps KN, Falkowski LB, Fox JG, Hendricks JC, Mexas AM, Rosol TJ, Stromberg BE.
J Vet Med Educ. 2009 Spring;36(1):62-9.
PMID: 19435991


Amy McCalla

A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.

Ferraz Nogueira Filho MA, Peer CJ, Nguyen J, McCalla A, Helman L, Figg WD.

J Pharm Biomed Anal. 2017 Jan 5;132:223-226. doi: 10.1016/j.jpba.2016.10.003.

PMID: 27768921

Polyomavirus-associated nephritis in 2 horses.

Jennings SH, Wise AG, Nickeleit V, Maes RK, Cianciolo RE, Del Piero F, Law JM, Kim Y, McCalla AC, Breuhaus BA, Roberts MC, Linder KE.

Vet Pathol. 2013 Sep;50(5):769-74. doi: 10.1177/0300985813476063. Epub 2013 Feb 4.

PMID: 23381926

Vesiculobullous skin reaction temporally related to firocoxib treatment in a white rhinoceros (Ceratotherium simum).

Stringer EM, De Voe RS, Linder K, Troan B, McCalla-Martin A, Loomis MR.

J Zoo Wildl Med. 2012 Mar;43(1):186-9.

PMID: 22448531

Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N.
McCalla-Martin AC, Chen X, Linder KE, Estrada JL, Piedrahita JA.
Transgenic Res. 2010 Oct;19(5):869-87. Epub 2010 Jan 23.
PMID: 20099029

Expression of the Arf tumor suppressor gene is controlled by Tgfbeta2 during development.
Freeman-Anderson NE, Zheng Y, McCalla-Martin AC, Treanor LM, Zhao YD, Garfin PM, He TC, Mary MN, Thornton JD, Anderson C, Gibbons M, Saab R, Baumer SH, Cunningham JM, Skapek SX.
Development. 2009 Jun;136(12):2081-9.
PMID: 19465598

Helen Michael

A Topical Solution to the Sunless Tanning Problem.

Michael HT, Merlino G.

Trends Mol Med. 2017 Sep;23(9):771-773. doi: 10.1016/j.molmed.2017.07.010. Epub 2017 Aug 5.

PMID: 28789829

Mouse models of UV-induced melanoma: genetics, pathology, and clinical relevance.

Day CP, Marchalik R, Merlino G, Michael H.

Lab Invest. 2017 Jan 16. doi: 10.1038/labinvest.2016.155. [Epub ahead of print]

PMID: 28092363

Synergistic targeted inhibition of MEK and dual PI3K/mTOR diminishes viability and inhibits tumor growth of canine melanoma underscoring its utility as a preclinical model for human mucosal melanoma.

Wei BR, Michael HT, Halsey CH, Peer CJ, Adhikari A, Dwyer JE, Hoover SB, El Meskini R, Kozlov S, Weaver Ohler Z, Figg WD, Merlino G, Simpson RM.

Pigment Cell Melanoma Res. 2016 Jul 27. doi: 10.1111/pcmr.12512. [Epub ahead of print]

PMID: 27463366

Functional analysis of prognostic gene expression network genes in metastatic breast cancer models.                

Geiger TR, Ha NH, Faraji F, Michael HT, Rodriguez L, Walker RC, Green JE, Simpson RM, Hunter KW.

PLoS One. 2014 Nov 4;9(11):e111813. doi: 10.1371/journal.pone.0111813. eCollection 2014.

PMID: 25368990

Isolation and characterization of canine natural killer cells.

Michael HT, Ito D, McCullar V, Zhang B, Miller JS, Modiano JF.

Vet Immunol Immunopathol. 2013 Sep 15;155(3):211-7. doi: 10.1016/j.vetimm.2013.06.013. Epub 2013 Jun 28

PMID: 23876304

Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma.
Simpson RM, Bastian BC, Michael HT, Webster JD, Prasad ML, Conway CM, Prieto VM, Gary JM, Goldschmidt MH, Esplin DG, Smedley RC, Piris A, Meuten DJ, Kiupel M, Lee CC, Ward JM, Dwyer JE, Davis BJ, Anver MR, Molinolo AA, Hoover SB, Rodriguez-Canales J, Hewitt SM.
Pigment Cell Melanoma Res. 2014 Jan;27(1):37-47. doi: 10.1111/pcmr.12185. Epub 2013 Nov 21.
PMID: 24128326

Tyler Peat

Pax8, Napsin A, and CD10 as Immunohistochemical Markers of Canine Renal Cell Carcinoma.

Peat TJ, Edmondson EF, Miller MA, DuSold DM, Ramos-Vara JA.

Vet Pathol. 2017 Jul;54(4):588-594. doi: 10.1177/0300985817698211. Epub 2017 Mar 27

PMID: 28346124

Characteristic lipid profiles of canine non-Hodgkin's lymphoma from surgical biopsy tissue sections and fine needle aspirate smears by desorption electrospray ionization--mass spectrometry.

Jarmusch AK, Kerian KS, Pirro V, Peat T, Thompson CA, Ramos-Vara JA, Childress MO, Cooks RG.

Analyst. 2015 Sep 21;140(18):6321-9. doi: 10.1039/c5an00825e.

PMID: 26236993


Michael Richardson


Amy Flis


Raisa Glabman



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