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2012 CBSTP Symposium and NIH Melanoma Tumor Board

2012 NIH Comparative Biomedical Scientist Training Program Symposium

April 18-19, 2012

Natcher Center, National Institutes of Health, Bethesda, MD

 

The Comparative Biomedical Scientist Training Program Symposium serves to provide a forum for highlighting comparative approaches to biomedical research.  The Comparative Biomedical Scientist Training Program (CBSTP) at the National Institutes of Health provides interdisciplinary training in comparative biomedical research, and human and veterinary pathology to doctors of veterinary medicine.  This training creates an opportunity for integrating a comparative perspective, acquired through incorporating a background in veterinary medicine and pathology with training in human biomedical research in an environment including basic research investigators and physician scientists.  This curriculum fosters shared vocabulary and approaches to translational research.   The program’s symposium highlights the research of trainees and other scientists, provides a platform for the presentation of comparative biomedical research, and serves as an opportunity to foster collaborative interactions between researchers, physicians, and veterinarian-scientists.

Scientific Session Featuring PhD Dissertation Research Work-In-Progress by CBSTP Fellows:  Platform presentations and a poster session on April 18 will feature research work-in-progress by trainees at NIH, as well as presentations of case studies undertaken during diagnostic training at partnership university teaching hospitals.

Scientific Session on Mouse Biology in the Animal Models of Human Disease Series:  Platform presentations by national and international experts on modeling human disease in mice will be featured on April 18.   

 

Scientific Session Focused on Comparative Melanoma Biology and Relevant Research and Clinical Challenges: The 2012 CBSTP Symposium will include a day-long scientific session (April 19, 2012) focusing on modeling the biology of melanoma disease and on the comparative pathology of melanomas.  Biomedical investigators with basic research and clinical interests in multiple species will participate in the scientific session.  This session will incorporate platform presentations on mouse and fish models of melanoma, as well as the clinical behavior and pathobiology of spontaneous melanomas in people and dogs in order to stimulate examination of the disease from a comparative perspective.  The goal is to compare the morphology, pathogenesis, and biology of both induced and spontaneous melanomas in multiple species.  The objectives include stimulating discussions and collaborations aimed at improving the comparative characterization of melanoma across different species, and appraising the utility of each model organism for preclinical studies useful to pilot therapeutic development. 

Collaborative Comparative Melanoma Tumor Board:  Following the scientific session, a panel of invited collaborating physician and veterinary pathologists will convene as a Comparative Melanoma Tumor Board to study dog and human mucosal melanomas, a specialized form of the human disease for which there may be considerable shared characteristics.  By addressing pathological disease occurring in the context of multiple species, the board will seek a consensus regarding the degree of comparability among the various species. The board will seek to further inform progress in cancer research aimed at benefiting both animal and human patients and to assess the utility of the dog as a preclinical model for mucosal melanomas in people.  The scientific session (see preliminary agenda) will serve as a preface to help inform the Comparative Melanoma Tumor Board serve to create a forum for open collaborative discussion, and to serve as a model for future, similar comparative biomedical conferences. 

Support for the meeting includes provision by The National Cancer Institute, The Animal Cancer Foundation, Inc., The Canine Comparative Oncology and Genomics Consortium, Inc., The National Institute of Allergy and Infectious Diseases, The National Institute of Neurological Disorders and Stroke, and The National Heart, Lung, and Blood Institute. 

 

 

2012 NIH Comparative Biomedical Scientist Training Program

Scientific Symposium

April 18-20, 2012

NIH Natcher Conference Center, Bethesda, Maryland

Agenda

 

   Wednesday, April 18, 2012                                                          Room E1/E2

                                  

8:15 am                   Welcome

                                    Introductions Mark Simpson, D.V.M., Ph.D., and Joshua Webster, D.V.M., Ph.D.,

                                    Molecular Pathology Unit, Laboratory Cancer Biology and Genetics, Center for Cancer

                                    Research, National Cancer Institute

 

8:25 am                   State of the Training Program

 

Presentation of Ph.D. Dissertation Research Work in Progress

CBSTP Fellows

 

8:45 am-9:15 am           Ian Moore, D.V.M.–  Laboratory of Infectious Disease, NIAID

                                    Title: The domestic ferret model of influenza infection and disease  pathogenesis:

                                    interesting features and phenomenon

 

9:15 am-9:45 am           Leah Zadrozny, D.V.M.–  Laboratory of Cardiac Energetics, NHLBI

                                     Title: Arterial wall macromolecular microstructure in SR-BI-/-/ApoeR61h/h mice:  a

                                     model for investigating human atherosclerotic disease and piloting interventions 

 

9:45 am-10:45 am         Comparative Biomedical Scientist Trainee Poster Session and Break

10:45 am-11:15 am        Sally Davis, D.V.M.–  Laboratory of Infectious Disease, NIAID   TBA

                                     Title: Multidrug-resistant 2009 pandemic influenza A(H1N1) viruses maintain

                                     equivalent pathology, fitness and transmissibility in ferrets

 

11:15 am-12:30 pm        Lunch 

 

Biology of Animal Models of Human Disease:  Mouse Biology

 

12:30 pm-1:15 pm         Lionel Feigenbaum, Ph.D.  –  Director, Laboratory Animal Science Program,

                                    NCI-Frederick , SAIC

                                    Title: Transgenic mice production: a technical perspective   

1:15 pm-2:00 pm          Lino Tessarollo, Ph.D. –  Deputy Program Director, Mouse Cancer GeneticsProgram,                                        head, Neural Development Section, NCI

                                    Title: Engineered mouse models to dissect gene function in vivo   

  

2:00 pm-2:45 pm          Rani Sellers, D.V.M., Ph.D. –  Associate Professor, Department of Pathology, Albert

                                    Einstein College of Medicine, Yeshiva University,  New York

                                    Title: ES cells, background strain, and phenotype

 

2:45 pm-3:00 pm        Break

 

3:00 pm-3:45 pm          Harm HogenEsch, D.V.M., Ph.D.  Professor, Purdue University

                                   Title: Immunodeficient mouse models in biomedical research  

 

 

4:30 pm-5:00 pm        Closing Remarks and Additional Opportunity to Visit Posters

 

 

 

Comparative Melanoma Biology

Scientific Session and Tumor Board

April 19-20, 2012

NIH Natcher Conference Center, Bethesda, Maryland

 

     Thursday, April 19, 2012                                                                Room E1/E2

                                  

8:00 am                 Director’s Welcome

                                   Richard G. Wyatt, M.D. Deputy Director, Office of Intramural Research,

                                   Office of the Director, NIH

 

                                   Introductions – Mark Simpson, D.V.M., Ph.D., and Stephen Hewitt, M.D., Ph.D.,

                                   Center for Cancer Research, NCI

Session 1:  Animal models of melanoma

8:15 am-8:55am           Craig J. Ceol, Ph.D. – Assistant Professor, University of Massachusetts Medical School,

                                    Worcester 

                                     Title: Understanding melanoma initiation using the zebrafish Danio rerio

8:55 am-9:35 am           Marcus W. Bosenberg, M.D., Ph.D. – Associate Professor, Yale University Medical

                                    School, New Haven

                                    Title: Comparative pathology of genetically engineered mouse models of melanoma

 

9:35 am-9:50 am         Break - visit fellow posters

 

9:50 am-10:30 am         Glenn Merlino, Ph.D. – Chief, Laboratory of Cancer Biology and Genetics, NCI, Bethesda

                                    Title: Modeling UV-initiated melanoma in the mouse

 

10:30 am-11:10 am        Sheri Holmen, Ph.D. – Associate Professor, Huntsman Cancer Institute, University of

                                     Utah, Salt Lake

                                     Title: A somatic cell gene delivery mouse model allows rapid evaluation of genes

                                     implicated in human melanoma

 

11:10 am-12:00 pm       Keynote Speaker   

                                      Boris Bastian, M.D., Ph.D. - Gerson and Barbara Barker Distinguished Professor of

                                      Cancer Biology, University of California, San Francisco

                                      Title: Integrating molecular and clinical features to improve the taxonomy of  

                                      melanocytic neoplasms

 

12:00 pm-1:15 pm         Lunch   

 

Session 2:  Human melanomas

1:15 pm-1:50 pm           Xiaohong Rose Yang, Ph.D., M.P.H. – Investigator, Genetic Epidemiology Branch,

                                    Division of Cancer Epidemiology and Genetics, NCI, Rockville

                                  Title: Genetic epidemiology of melanoma

 

1:50 pm-2:25 pm          Adriano Piris, M.D. – Assistant in Pathology, Massachusetts General Hospital, Instructor

                                   in Pathology, Harvard Medical School, Boston

                                   Title: Metastatic malignant melanoma and selective BRAF inhibitor therapy 

 

2:25 pm-3:00 pm          Victor Prieto, M.D., Ph.D. – Professor of Pathology and Dermatology Section Chief,

                                   Dermatopathology, Department of Pathology, MD Anderson Cancer Center,

                                   Univ of Texas, Houston

                                   Title: Histopathology and prognostic factors

 

3:00 pm-3:15 pm          Break –  visit fellow posters

 

Session 3:  Canine melanomas

3:15 pm-3:55 pm          Philip J. Bergman, D.V.M., Ph.D. – Chief Medical Officer, BrightHeart Veterinary

                                   Centers, Armonk, New York

                                   Title: Of mice & men (and dogs!): xenogeneic DNA vaccines for canine melanoma &

                                   other spontaneous malignancies

 

3:55 pm-4:35 pm          Rebecca Smedley, D.V.M., M.S. – Academic Specialist, Diagnostic Center for Population

                                   and Animal Health, Michigan State University, Lansing

                                   Title: Review of the prognostic evaluation of canine melanomas

 

4:35 pm                        Closing remarks

 

 

    Thursday, April 19, 2012   (6pm-9pm )                               Bethesda North Marriott

  Tumor board commences Working Session including Evening Speaker

(Thursday Evening, by invitation only – at Bethesda North Marriott)

 

7:00 pm                        Evening Speaker

                                    Chand Khanna, D.V.M., Ph.D. – Head, Tumor and Metastasis Biology Section,

                                    Pediatric  Oncology Branch, NCI, Bethesda

                                    Title: A comparative approach to cancer biology and therapy

 

 

Friday, April 20, 2012   (8am-2:30pm)          NIH Natcher Conference Center, Room D

  Comparative Melanoma Tumor Board Session (limited space, by invitation)

 

8:00 am     Tumor Board Working Session – Moderated by Mark Simpson, D.V.M., Ph.D.,

                 Laboratory of Cancer Biology and Genetics, NCI, and Stephen Hewitt, M.D., Ph.D.,

                 Laboratory of Pathology, NCI

 

2:30 pm      Meeting adjourns

 

NIH Comparative Melanoma

Tumor Board Members

 

Tumor Board Organizers 

R. Mark Simpson, D.V.M., Ph.D.

Head, Molecular Pathology Unit

Director, NIH Comparative Biomedical

Scientist Training Program

Laboratory of Cancer Biology and Genetics, Center for Cancer Research,

National Cancer Institute

Bethesda, MD

Joshua D. Webster, D.V.M., Ph.D.

Staff Scientist

Laboratory of Cancer Biology and

Genetics, Center for Cancer Research,

National Cancer Institute

Bethesda, MD

Stephen M. Hewitt, M.D., Ph.D.

Head, Tissue Array Research Program

Head, Advanced Molecular Pathology Section, Laboratory of Pathology

Center for Cancer Research,

National Cancer Institute

Bethesda, MD

Joy Gary, D.V.M.

Fellow, NIH Comparative Biomedical

Scientist Training Program

Laboratory of Cancer Biology and

Genetics, Center for Cancer Research,

National Cancer Institute

Bethesda, MD

          

Jaime Rodriguez-Canales, M.D.

Pathologist

Laser Microdissection Laboratory

Laboratory of Pathology,

Center for Cancer Research,

National Cancer Institute

Bethesda, MD

 

 

Collaborating Physician and Veterinary Pathologist Diagnostic Specialists

Boris C. Bastian, M.D., Ph.D.             Clinical Professor

Department of Dermatology

University of California, San Francisco

Donald J. Meuten, D.V.M., Ph.D.

Professor, Department of Population

Health and Pathobiology

North Carolina State University

Raleigh, NC

 

Marcus W. Bosenberg, M.D., Ph.D.

Associate Professor of Dermatology

and Pathology

Yale University School of Medicine

Yale Cancer Center

New Haven, CT 

 

Adriano Piris, M.D.

Assistant in Pathology

Massachusetts General Hospital

Instructor in Pathology

Harvard Medical School

Boston, MA

D. Glen Esplin, D.V.M., Ph.D.

Vice President and Medical Director

Animal Reference Pathology

ARUP Laboratories

University of Utah

Salt Lake City, UT

Manju Prasad, M.D., MBBS

Associate Professor of Pathology

Director, Endocrine, Head & Neck Pathology

Director, Immunohistochemistry Laboratory

Department of Pathology

Yale University

New Haven, CT

 

Michael H. Goldschmidt, B.V.M.S, M.Sc.

Professor of Pathology

Head, Surgical Pathology

Department of Pathobiology

University of Pennsylvania

Philadelphia, PA

Victor G. Prieto, M.D., Ph.D.

Professor of Pathology and Dermatology

Section Chief, Dermatopathology

Department of Pathology

MD Anderson Cancer Center

University of Texas

Houston, TX

 

Matti Kiupel, Dr. Med. Vet, Ph.D.

Associate Professor

Department of Pathobiology and

Diagnostic Investigation

Michigan State University

East Lansing, MI

Rebecca C. Smedley, D.V.M., M.S.

Academic Specialist

Diagnostic Center for Population

and Animal Health

Michigan State University

Lansing, MI

Chyi-Chia Richard Lee, M.D., Ph.D.

Staff Clinician

Laboratory of Pathology

National Cancer Institute

Bethesda, MD

Capitol Dermatopathology Laboratories

Rockville, MD

 

 

Tumor Board Adjunct Pathologists

Miriam Anver, D.V.M., Ph.D.

Senior Pathologist

Science Applications International Corporation

National Cancer Institute-Frederick

Frederick, MD

Alfredo Alberto Molinolo, M.D., Ph.D.

Staff Scientist, Pathologist

Oral & Pharyngeal Cancer Branch

National Institute of Dental and

Craniofacial Research

Bethesda, MD

 

 

 

 

2010 CBSTP Symposium

2010 NIH Comparative Biomedical Scientist Training Program Symposium

September 8-10, 2010

Natcher Center, National Institutes of Health, Bethesda, MD

The 2010 CBSTP Symposium was held in the NIH Natcher Conference Center September 8-10, 2010, honoring the partnership established for interdisciplinary training of veterinarians in comparative pathology and biomedical research. Scientific sessions, included presentations by outstanding investigators from our partnership universities, by NIH principal investigators, and 6 of our trainee veterinarians presented their original scholarship in research.

 

Our objectives in this second symposium were 1) to highlight research and research training being accomplished by veterinarians training in the NIH GPP interdisciplinary DVM/PhD training program, 2) to inform our veterinary college-GPP university partners about NIH research, and to 3) develop interactive collaborations among partnership university faculty and NIH investigators.

 

Highlights

 

The featured presentation was delivered by Michael Lenardo, M.D. of the National Institute of Allergy and Infectious Diseases, Laboratory of Immunology.  Dr. Lenardo directs another NIH Graduate Partnership training program known as the NIH Oxford Cambridge Scholars Program. his talk was entitled “International Collaboration Elucidates Severe Acute Respiratory Syndrome (SARS) Pathogenesis”. 

 

A pre-meeting workshop on the Biology Of Animal Models Of Human Diseases, focused on nonhuman primate biology and pathology, was held on September the 8th.   The symposium concluded with a workshop featuring a career planning/development session. 

 

This symposium also included 9 veterinary students, who through a competitive essay contest, won travel awards to allow them to participate in the symposium and present their current work as a poster presentation.  These invitees from across the U.S., are listed in our meeting proceedings booklet and appear in a photo below. 

 

2010 Symposium Poster Presentation

Dr. Heather Tillman explains her research to  Dr. Jennifer Thomas, Associate Professor at Michigan State University Dr. Heather Tillman explains her research to Dr. Jennifer Thomas,                 Associate Professor at Michigan State University.

Dr. Ian Moore talks with invited speaker Dr. Barb Davis, from Tufts UniversityDr. Ian Moore talks with invited speaker Dr. Barb Davis,                                   from Tufts University.

Dr. Schantel Hayes converses with Dr. Susan Ewart, Associate Dean of Research and Graduate Studies at Michigan State UniversityDr. Schantel Hayes converses with Dr. Susan Ewart,                                         Associate Dean of Research and Graduate Studies at                                       Michigan State University.

Travel Awards for Veterinary Students to Attend the 2010
CBSTP Symposium

In 2010,for the first time, travel awards were provided for veterinary students to attend the symposium. Students competed for awards by providing essays about their vision for research within their career goals and why they would like to attend the symposium. All submissions were evaluated and the top 9 students were provided travel awards to participate in the symposium.

Veterinary Medical Student Travel Award

2010 Travel Award Recipients

2010 Travel Award Recipients

From left to right: Mark Simpson (CBSTP Program Director, MPU. Head) Ashley Talley (Kansas State University), Michelle Cook Sangar (University of Pennsylvania), Tim Kurt (Colorado State University), Caroline Piskun (University of Wisconsin), Jeffrey Norris (University of California, Davis), Josh Webster (MPU Staff Pathologist), Claire Fellman (Mississippi State University) , and Koji Yasuda (Cornell University) Not pictured: Noelle Knight (University of Pennsylvania) and Lei Wang (University of Illinois)

Links to Open Proceedings Booklets

2008 Symposium Booklet 2010 Symposium Booklet 2012 Symposium BookletTumor Board Agenda 2013

Back to Top • This page last reviewed: May 24, 2013

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